Motile and non-motile (primary) cilia are nearly ubiquitous cellular organelles. The
dysfunction of cilia causes diseases known as ciliopathies. The number of reported …

Multiciliated cells are epithelial cells that are in contact with bodily fluids and are required for
the proper function of major organs including the brain, the respiratory system and the …

A finely regulated system of airway epithelial development governs the differentiation of
motile ciliated cells of the human respiratory tract, conferring the body's mucociliary …

Cigarette smoke first interacts with the lung through the cellularly diverse airway epithelium
and goes on to drive development of most chronic lung diseases. Here, through single cell …

Cilia play many essential roles in fluid transport and cellular locomotion, and as sensory
hubs for a variety of signal transduction pathways. Despite having a conserved basic …

Cilia are microtubule-based projections that serve a wide variety of essential functions in
animal cells. Defects in cilia structure or function have recently been found to underlie …

Ciliopathies are a growing class of disorders caused by abnormal ciliary axonemal structure
and function. Our understanding of the complex genetic and functional phenotypes of these …

Heterotaxy is a disorder of left–right body patterning, or laterality, that is associated with
major congenital heart disease. The aetiology and mechanisms underlying most cases of …

Motile multiciliated cells (MCCs) have critical roles in respiratory health and disease and are
essential for cleaning inhaled pollutants and pathogens from airways. Despite their …

Ependymoma (EPN) is a brain tumor commonly presenting in childhood that remains fatal in
most children. Intra-tumoral cellular heterogeneity in bulk-tumor samples significantly …