Multiple system atrophy: pathology, pathogenesis, and path forward

A Ndayisaba, GM Halliday… - Annual Review of …, 2024 - annualreviews.org
Multiple system atrophy (MSA) is a fatal neurodegenerative disease characterized by
autonomic failure and motor impairment. The hallmark pathologic finding in MSA is …

Neuro-Urology and Biobanking: An Integrated Approach for Advancing Research and Improving Patient Care

SM Botter, TM Kessler - International Journal of Molecular Sciences, 2023 - mdpi.com
Understanding the molecular mechanisms underlying neuro-urological disorders is crucial
for the development of targeted therapeutic interventions. Through the establishment of …

Combining alpha-synuclein PET and seeded-amplification to improve diagnostic accuracy of Multiple System Atrophy

V Khurana, D Rodriguez, B Changizi, C Sandiego… - 2024 - researchsquare.com
Biomarkers that facilitate early detection and track disease progression are an enormous
unmet need in neurodegenerative diseases and their clinical trials. Accurate diagnosis in …

[引用][C] Preparing for Disease‐Modification Trials in Degenerative Cerebellar Ataxias: Which Endpoints to Choose?

RP Maas - Movement Disorders, 2023 - Wiley Online Library
Building on decades of observational and preclinical studies, the field of degenerative
ataxias is currently preparing or—in the case of multiple system atrophy of cerebellar type …