Respiratory syncytial virus infection and novel interventions

AC Langedijk, LJ Bont - Nature Reviews Microbiology, 2023 - nature.com
The large global burden of respiratory syncytial virus (RSV) respiratory tract infections in
young children and older adults has gained increased recognition in recent years. Recent …

The road to approved vaccines for respiratory syncytial virus

TJ Ruckwardt - NPJ vaccines, 2023 - nature.com
After decades of work, several interventions to prevent severe respiratory syncytial virus
(RSV) disease in high-risk infant and older adult populations have finally been approved …

Correlative montage parallel array cryo-tomography for in situ structural cell biology

JE Yang, MR Larson, BS Sibert, JY Kim, D Parrell… - Nature …, 2023 - nature.com
Imaging large fields of view while preserving high-resolution structural information remains a
challenge in low-dose cryo-electron tomography. Here we present robust tools for montage …

Coinfection by influenza A virus and respiratory syncytial virus produces hybrid virus particles

J Haney, S Vijayakrishnan, J Streetley, K Dee… - Nature …, 2022 - nature.com
Interactions between respiratory viruses during infection affect transmission dynamics and
clinical outcomes. To identify and characterize virus–virus interactions at the cellular level …

Cryo-electron tomography to study viral infection

M Graham, P Zhang - Biochemical Society Transactions, 2023 - portlandpress.com
Developments in cryo-electron microscopy (cryo-EM) have been interwoven with the study
of viruses ever since its first applications to biological systems. Following the success of …

All Eyes on the Prefusion-Stabilized F Construct, but Are We Missing the Potential of Alternative Targets for Respiratory Syncytial Virus Vaccine Design?

S Schaerlaekens, L Jacobs, K Stobbelaar, P Cos… - Vaccines, 2024 - mdpi.com
Respiratory Syncytial Virus (RSV) poses a significant global health concern as a major
cause of lower respiratory tract infections (LRTIs). Over the last few years, substantial efforts …

Structural landscape of the respiratory syncytial virus nucleocapsids

L Gonnin, A Desfosses, M Bacia-Verloop… - Nature …, 2023 - nature.com
Abstract Human Respiratory Syncytial Virus (HRSV) is a prevalent cause of severe
respiratory infections in children and the elderly. The helical HRSV nucleocapsid is a …

Imaging analysis reveals budding of filamentous human metapneumovirus virions and direct transfer of inclusion bodies through intercellular extensions

F El Najjar, SR Castillo, CL Moncman, CY Wu, E Isla… - Mbio, 2023 - Am Soc Microbiol
Human metapneumovirus (HMPV) can spread between cells through budding of virus
particles or direct cell-to-cell spread. A network of budding filaments and intercellular …

Assembly of respiratory syncytial virus matrix protein lattice and its coordination with fusion glycoprotein trimers

BS Sibert, JY Kim, JE Yang, Z Ke, CC Stobart… - Nature …, 2024 - nature.com
Respiratory syncytial virus (RSV) is an enveloped, filamentous, negative-strand RNA virus
that causes significant respiratory illness worldwide. RSV vaccines are available, however …

[HTML][HTML] Integrating immunoinformatics and computational epitope prediction for a vaccine candidate against respiratory syncytial virus

TL Nguyen, H Kim - Infectious Disease Modelling, 2024 - Elsevier
Respiratory syncytial virus (RSV) poses a significant global health threat, especially affecting
infants and the elderly. Addressing this, the present study proposes an innovative approach …