The detailed understanding of chemical reactions still represents a major challenge for
experimental as well as theoretical chemists. The enormous progress in both hard-and …

The effect of different N− N spectator ligands on the reactivity of platinum (II) complexes was
investigated by studying the water lability of [Pt (diaminocyclohexane)(H2O) 2] 2+(Pt …

Interactions of hydrated cisplatin complexes with sulphur-containing amino acids cysteine
and methionine were explored. The square-planar cis-[Pt (NH3) 2 (H2O) X]+ complexes …

The trans effect and trans influence were investigated and rationalized in the aminolysis, a
typical nucleophilic substitution reaction, of trans-TPtCl2NH3 complexes (T= NH3, PH3, CO …

The mechanism of substitution water exchange reactions in square planar trans‐Pt [(NH3)
2T (H2O)] n+ complexes is studied (T H2O, NH3, OH−, F−, Cl−, Br−, H2S, CH3S−, SCN …

The thermodynamic and kinetic aspects of hydration reactions of cis‐/transplatin were
explored. The polarizable continuum model was used for estimation of solvent effects. Using …

The kinetic competition of sulfur and nitrogen nucleophiles L in the substitution reactions of
cisplatin derivatives, cis-[PtII (NH3) 2 (X)(OH2)] n++ L→ cis-[PtII (NH3) 2 (X)(L)] m++ H2O …

A hydrolysis process of the anticancer drug ImH [trans-Ru (III) Cl4 (DMSO)(Im)](nicknamed
NAMI-A; Im= imidazole, DMSO= dimethyl sulfoxide) has been studied by using density …

Prompted by the antineoplastic properties of cisplatin, a plethora of platinum (II)-based
complexes have been synthesized in the past decades. At present, their rational design is …

Density functional calculations on a range of hydrogen bonded clusters of cisplatin are
reported. A systematic search of 1: 1 cisplatin: water complexes reveals only three stable …