Radiometals comprise many useful radioactive isotopes of various metallic elements. When
properly harnessed, these have valuable emission properties that can be used for …

Metal complexes of DOTA (1, 4, 7, 10-tetraazacyclododecane-1, 4, 7, 10-tetraacetic acid)−
peptide conjugates are increasingly used as targeted imaging and therapeutic …

Targeted alpha-particle therapy (TAT) aims to selectively deliver radionuclides emitting α-
particles (cytotoxic payload) to tumors by chelation to monoclonal antibodies, peptides or …

1, 4, 7, 10-Tetraazacyclododecane-N, N′, N ″, N′″-tetraacetic acid (DOTA) is one of the
preeminent carriers of metal-based radiopharmaceutics and imaging contrast agents. This …

Monoclonal antibodies have become a viable strategy for the delivery of therapeutic, particle
emitting radionuclides specifically to tumor cells to either augment anti-tumor action of the …

Targeted α-particle therapy offers the potential for more specific tumor cell killing with less
damage to surrounding normal tissue than β-emitters because of the combination of short …

A bifunctional derivative of the versatile acyclic chelator H4octapa, p-SCN-Bn-H4octapa, has
been synthesized for the first time. The chelator was conjugated to the HER2/neu-targeting …

These studies demonstrate the feasibility of targeted therapy for the treatment of
disseminated peritoneal disease using 212Pb-labeled Herceptin as an in vivo generator of …

We report a practical and high-yield synthesis of a bimodal bifunctional ligand 3p-C-NETA-
NCS containing the isothiocyanate group for conjugation to a tumor targeting antibody. 3p-C …

INTRODUCTION: Despite the great potential of targeted α-radioimmunotherapy (RIT) as
demonstrated by pre-clinical and clinical trials, limited progress has been made on the …