Zinc (Zn) is a vital element. It plays indispensable roles in multifarious cellular processes,
affecting the expression and activity of a variety of molecules, including transcription factors …

Multiple classes of cell surface receptors and ion channels participate in the detection of
changes in environmental stimuli, and thereby influence animal behavior. Among the many …

Aberrant zinc (Zn) homeostasis is associated with abnormal control of mammalian growth,
although the molecular mechanisms of Zn's roles in regulating systemic growth remain to be …

TRPM7 (transient receptor potential cation channel subfamily M member 7) regulates gene
expression and stress-induced cytotoxicity and is required in early embryogenesis through …

The trace element zinc (Zn) binds to over ten percent of proteins in eukaryotic cells. Zn
flexible chemistry allows it to regulate the activity of hundreds of enzymes and influence …

The basic mechanisms underlying noxious cold perception are not well understood. We
developed Drosophila assays for noxious cold responses. Larvae respond to near-freezing …

Transient receptor potential (TRP) channels form a diverse family of cation channels
comprising 28 members in mammals. Although some TRP proteins can only be found on …

The channel kinases TRPM6 and TRPM7 are fusion proteins with an ion transport domain
and an enzymatically active kinase domain. TRPM7 has been found in every mammalian …

Maintenance of metal homeostasis is crucial for many different enzymatic activities and in
turn for cell function and survival. In addition, cells display detoxification and protective …

Developmental bioelectricity is the study of the endogenous role of bioelectrical signaling in
all cell types. Resting potentials and other aspects of ionic cell physiology are known to be …