New developments in anti-malarial target candidate and product profiles
JN Burrows, S Duparc, WE Gutteridge… - Malaria journal, 2017 - Springer
A decade of discovery and development of new anti-malarial medicines has led to a
renewed focus on malaria elimination and eradication. Changes in the way new anti …
renewed focus on malaria elimination and eradication. Changes in the way new anti …
[HTML][HTML] Progress with Plasmodium falciparum sporozoite (PfSPZ)-based malaria vaccines
TL Richie, PF Billingsley, BKL Sim, ER James… - Vaccine, 2015 - Elsevier
Sanaria Inc. has developed methods to manufacture, purify and cryopreserve aseptic
Plasmodium falciparum (Pf) sporozoites (SPZ), and is using this platform technology to …
Plasmodium falciparum (Pf) sporozoites (SPZ), and is using this platform technology to …
Controlled human infection models to accelerate vaccine development
RKM Choy, AL Bourgeois… - Clinical Microbiology …, 2022 - Am Soc Microbiol
The timelines for developing vaccines against infectious diseases are lengthy, and often
vaccines that reach the stage of large phase 3 field trials fail to provide the desired level of …
vaccines that reach the stage of large phase 3 field trials fail to provide the desired level of …
Sporozoite immunization: innovative translational science to support the fight against malaria
TL Richie, LWP Church, T Murshedkar… - Expert review of …, 2023 - Taylor & Francis
Introduction Malaria, a devastating febrile illness caused by protozoan parasites, sickened
247,000,000 people in 2021 and killed 619,000, mostly children and pregnant women in …
247,000,000 people in 2021 and killed 619,000, mostly children and pregnant women in …
A systematic review of human challenge trials, designs, and safety
J Adams-Phipps, D Toomey, W Więcek… - Clinical Infectious …, 2023 - academic.oup.com
Background Few studies have assessed participant safety in human challenge trials (HCTs).
Key questions regarding HCTs include how risky such trials have been, how often adverse …
Key questions regarding HCTs include how risky such trials have been, how often adverse …
Impact of sickle cell trait and naturally acquired immunity on uncomplicated malaria after controlled human malaria infection in adults in Gabon
Controlled human malaria infection (CHMI) by direct venous inoculation (DVI) with 3,200
cryopreserved Plasmodium falciparum sporozoites (PfSPZ) consistently leads to parasitemia …
cryopreserved Plasmodium falciparum sporozoites (PfSPZ) consistently leads to parasitemia …
[HTML][HTML] Safety, immunogenicity, and protective efficacy of intradermal immunization with aseptic, purified, cryopreserved Plasmodium falciparum sporozoites in …
GJH Bastiaens, MPA van Meer… - The American journal …, 2016 - ncbi.nlm.nih.gov
Immunization of volunteers under chloroquine prophylaxis by bites of Plasmodium
falciparum sporozoite (PfSPZ)–infected mosquitoes induces> 90% protection against …
falciparum sporozoite (PfSPZ)–infected mosquitoes induces> 90% protection against …
Fast and fierce versus slow and smooth: Heterogeneity in immune responses to Plasmodium in the controlled human malaria infection model
XZ Yap, MBB McCall, RW Sauerwein - Immunological Reviews, 2020 - Wiley Online Library
Controlled human malaria infection (CHMI) is an established model in clinical malaria
research. Upon exposure to Plasmodium falciparum parasites, malaria‐naive volunteers …
research. Upon exposure to Plasmodium falciparum parasites, malaria‐naive volunteers …
Development of whole sporozoite malaria vaccines
MR Hollingdale, M Sedegah - Expert review of vaccines, 2017 - Taylor & Francis
Introduction: Despite recent advances, malaria remains a major health threat both to
populations in endemic areas as well travelers, including military personnel, to these areas …
populations in endemic areas as well travelers, including military personnel, to these areas …
[HTML][HTML] Liver enzyme elevations in Plasmodium falciparum volunteer infection studies: findings and recommendations
MF Chughlay, S Akakpo, A Odedra… - The American Journal …, 2020 - ncbi.nlm.nih.gov
Malaria volunteer infection studies (VISs) accelerate new drug and vaccine development. In
the induced blood-stage malaria (IBSM) model, volunteers are inoculated with erythrocytes …
the induced blood-stage malaria (IBSM) model, volunteers are inoculated with erythrocytes …