New developments in anti-malarial target candidate and product profiles

JN Burrows, S Duparc, WE Gutteridge… - Malaria journal, 2017 - Springer
A decade of discovery and development of new anti-malarial medicines has led to a
renewed focus on malaria elimination and eradication. Changes in the way new anti …

[HTML][HTML] Progress with Plasmodium falciparum sporozoite (PfSPZ)-based malaria vaccines

TL Richie, PF Billingsley, BKL Sim, ER James… - Vaccine, 2015 - Elsevier
Sanaria Inc. has developed methods to manufacture, purify and cryopreserve aseptic
Plasmodium falciparum (Pf) sporozoites (SPZ), and is using this platform technology to …

Controlled human infection models to accelerate vaccine development

RKM Choy, AL Bourgeois… - Clinical Microbiology …, 2022 - Am Soc Microbiol
The timelines for developing vaccines against infectious diseases are lengthy, and often
vaccines that reach the stage of large phase 3 field trials fail to provide the desired level of …

Sporozoite immunization: innovative translational science to support the fight against malaria

TL Richie, LWP Church, T Murshedkar… - Expert review of …, 2023 - Taylor & Francis
Introduction Malaria, a devastating febrile illness caused by protozoan parasites, sickened
247,000,000 people in 2021 and killed 619,000, mostly children and pregnant women in …

A systematic review of human challenge trials, designs, and safety

J Adams-Phipps, D Toomey, W Więcek… - Clinical Infectious …, 2023 - academic.oup.com
Background Few studies have assessed participant safety in human challenge trials (HCTs).
Key questions regarding HCTs include how risky such trials have been, how often adverse …

Impact of sickle cell trait and naturally acquired immunity on uncomplicated malaria after controlled human malaria infection in adults in Gabon

B Lell, B Mordmüller, JCD Agobe… - … American journal of …, 2017 - pmc.ncbi.nlm.nih.gov
Controlled human malaria infection (CHMI) by direct venous inoculation (DVI) with 3,200
cryopreserved Plasmodium falciparum sporozoites (PfSPZ) consistently leads to parasitemia …

[HTML][HTML] Safety, immunogenicity, and protective efficacy of intradermal immunization with aseptic, purified, cryopreserved Plasmodium falciparum sporozoites in …

GJH Bastiaens, MPA van Meer… - The American journal …, 2016 - ncbi.nlm.nih.gov
Immunization of volunteers under chloroquine prophylaxis by bites of Plasmodium
falciparum sporozoite (PfSPZ)–infected mosquitoes induces> 90% protection against …

Fast and fierce versus slow and smooth: Heterogeneity in immune responses to Plasmodium in the controlled human malaria infection model

XZ Yap, MBB McCall, RW Sauerwein - Immunological Reviews, 2020 - Wiley Online Library
Controlled human malaria infection (CHMI) is an established model in clinical malaria
research. Upon exposure to Plasmodium falciparum parasites, malaria‐naive volunteers …

Development of whole sporozoite malaria vaccines

MR Hollingdale, M Sedegah - Expert review of vaccines, 2017 - Taylor & Francis
Introduction: Despite recent advances, malaria remains a major health threat both to
populations in endemic areas as well travelers, including military personnel, to these areas …

[HTML][HTML] Liver enzyme elevations in Plasmodium falciparum volunteer infection studies: findings and recommendations

MF Chughlay, S Akakpo, A Odedra… - The American Journal …, 2020 - ncbi.nlm.nih.gov
Malaria volunteer infection studies (VISs) accelerate new drug and vaccine development. In
the induced blood-stage malaria (IBSM) model, volunteers are inoculated with erythrocytes …