Normothermic machine perfusion of the kidney: better conditioning and repair?

SA Hosgood, E van Heurn… - Transplant …, 2015 - Wiley Online Library
Kidney transplantation is limited by hypothermic preservation techniques. Prolonged periods
of cold ischaemia increase the risk of early graft dysfunction and reduce long‐term survival …

Extended-criteria donors in liver transplantation Part II: reviewing the impact of extended-criteria donors on the complications and outcomes of liver transplantation

B Nemes, G Gámán, WG Polak, F Gelley… - Expert review of …, 2016 - Taylor & Francis
Extended-criteria donors (ECDs) have an impact on early allograft dysfunction (EAD), biliary
complications, relapse of hepatitis C virus (HCV), and survivals. Early allograft dysfunction …

[HTML][HTML] Liver preservation with machine perfusion and a newly developed cell-free oxygen carrier solution under subnormothermic conditions

P Fontes, R Lopez, A Van Der Plaats… - American journal of …, 2015 - Elsevier
We describe a new preservation modality combining machine perfusion (MP) at
subnormothermic conditions (21° C) with a new hemoglobin-based oxygen carrier (HBOC) …

[HTML][HTML] Towards the creation of decellularized organ constructs using irreversible electroporation and active mechanical perfusion

MB Sano, RE Neal, PA Garcia, D Gerber… - Biomedical engineering …, 2010 - Springer
Background Despite advances in transplant surgery and general medicine, the number of
patients awaiting transplant organs continues to grow, while the supply of organs does not …

[HTML][HTML] “Resuscitation” of marginal liver allografts for transplantation with machine perfusion technology

JA Graham, JV Guarrera - Journal of hepatology, 2014 - Elsevier
As the rate of medically suitable donors remains relatively static worldwide, clinicians have
looked to novel methods to meet the ever-growing demand of the liver transplant waiting …

[HTML][HTML] Biomarkers to assess graft quality during conventional and machine preservation in liver transplantation

CJ Verhoeven, WRR Farid, J de Jonge… - Journal of …, 2014 - Elsevier
A global rising organ shortage necessitates the use of extended criteria donors (ECD) for
liver transplantation (LT). However, poor preservation and extensive ischemic injury of ECD …

Subnormothermic machine perfusion at both 20 C and 30 C recovers ischemic rat livers for successful transplantation

H Tolboom, ML Izamis, N Sharma, JM Milwid… - Journal of Surgical …, 2012 - Elsevier
BACKGROUND: Utilizing livers from donors after cardiac death could significantly expand
the donor pool. We have previously shown that normothermic (37° C) extracorporeal liver …

[HTML][HTML] Oxygen generating biomaterials preserve skeletal muscle homeostasis under hypoxic and ischemic conditions

CL Ward, BT Corona, JJ Yoo, BS Harrison, GJ Christ - PloS one, 2013 - journals.plos.org
Provision of supplemental oxygen to maintain soft tissue viability acutely following trauma in
which vascularization has been compromised would be beneficial for limb and tissue …

[HTML][HTML] Machine perfusion in liver transplantation as a tool to prevent non-anastomotic biliary strictures: rationale, current evidence and future directions

PD Weeder, R van Rijn, RJ Porte - Journal of hepatology, 2015 - Elsevier
The high incidence of non-anastomotic biliary strictures (NAS) after transplantation of livers
from extended criteria donors is currently a major barrier to widespread use of these organs …

Protective effects of hypothermic ex vivo perfusion on ischemia/reperfusion injury and transplant outcomes

SD Henry, JV Guarrera - Transplantation reviews, 2012 - Elsevier
Hypothermic machine preservation (HMP) has been used in renal transplantation since the
late 1960s with recent robust prospective, multicenter data showing lower rates of delayed …