Infections with protozoan parasites are a major cause of disease and mortality in many
tropical countries of the world. Diseases caused by species of the genera Trypanosoma …

Chagas disease is a neglected tropical disease caused by the protozoan Trypanosoma
cruzi. Currently, only nitroheterocyclic nifurtimox (NFX) and benznidazole (BNZ) are …

HPLC-UV-ELSD-MS-guided fractionation of the anti-parasitic extract obtained from the
marine sponge Monanchora arbuscula, collected off the southeastern coast of Brazil, led to …

The fractionation through bioguided antileishmanial activity of the dichloromethane extract of
Cassia fistula fruits (Leguminosae) led to the isolation of the active isoflavone biochanin A …

The isolation and identification of a series of new pseudoceratidine (1) derivatives from the
sponge Tedania brasiliensis enabled the evaluation of their antiparasitic activity against …

Background The neglected human diseases caused by trypanosomatids are currently
treated with toxic therapy with limited efficacy. In search for novel anti-trypanosomatid …

Investigation of the bioactive crude extract from the sponge Plakortis angulospiculatus from
Brazil led to the isolation of plakortenone (1) as a new polyketide, along with five known …

It is well established that L-proline has several roles in the biology of trypanosomatids. In
Trypanosoma cruzi, the etiological agent of Chagas' disease, this amino acid is involved in …

Chagas disease is caused by the parasitic protozoan Trypanosoma cruzi. It has high
mortality as well as morbidity rates and usually affects the poorer sections of the population …

Chagas disease (CD) caused by the protozoan Trypanosoma cruzi affects more than six
million people worldwide. Treatment is restricted to benznidazole (Bz) and nifurtimox (Nf) …