Alimentary and endogenous proteins are mixed in the small intestinal lumen with the
microbiota. Although experimental evidences suggest that the intestinal microbiota is able to …

The polyamine-biosynthetic pathway represents an inviting target for the development of
agents inhibiting carcinogenesis and tumor growth. Polyamines play an essential role in the …

Background L-arginine is considered to be one of the most versatile amino acids due to the
fact that it serves as a precursor for many important molecules in cellular physiology. When …

The polyamines putrescine, spermidine and spermine represent a group of naturally
occurring compounds exerting a bewildering number of biological effects, yet despite …

The human methylthioadenosine phosphorylase (MTAP) gene is located on 9p21 and is
frequently homozygously deleted, along with p16cdkN2a/ARF, in a wide variety of human …

The polyamines spermidine and spermine and their precursor putrescine are intimately
involved in and are required for cell growth and proliferation. This study examines the …

Treatment of patients with triple-negative breast cancer (TNBC) is limited by a lack of
effective molecular therapies targeting this disease. Recent studies have identified …

Background The majority of cancer cells have a unique metabolic requirement for
methionine that is not observed in normal, non-tumorigenic cells. This phenotype is …

Although polyamines are well recognized for their critical involvement in cell growth, the cell
cycle specificity of this requirement has not yet been characterized with respect to the newly …

Introduction 3. Metabolism and physiological effects of polyamines and nitric oxide on
normal and cancerous colonic epithelial cells 3.1. Metabolism of L-arginine in the polyamine …