Alzheimer's disease, a neurodegenerative disease with amyloid beta accumulation as a
major hallmark, has become a dire global health concern as there is a lack of clear …

Neuroinflammation commences decades before Alzheimer's disease (AD) clinical onset and
represents one of the earliest pathomechanistic alterations throughout the AD continuum …

Compelling experimental evidence suggests that microglial activation is involved in the
spread of tau tangles over the neocortex in Alzheimer's disease (AD). We tested the …

Background Astrocytes, also called astroglia, maintain homoeostasis of the brain by
providing trophic and metabolic support to neurons. They recycle neurotransmitters …

Highlights•Host-derived molecules (eg β-amyloid, tau) trigger NLRP3 inflammasome
signaling.•TNF, ATP, serum amyloid A and the microbiome regulate NLRP3 inflammasome …

Inflammatory processes and proinflammatory cytokines have a key role in the cellular
processes of neurodegenerative diseases and are linked to the pathogenesis of functional …

Alzheimer's disease's pathophysiology is still a conundrum. Growing number of evidences
have elucidated the involvement of oxidative stress in the pathology of AD rendering it a …

The inhibition of the enzyme soluble epoxide hydrolase (sEH) has demonstrated clinical
therapeutic effects in several peripheral inflammatory-related diseases, with 3 compounds in …

Nervous tissue homeostasis requires the regulation of microglia activity. Using conditional
gene targeting in mice, we demonstrate that genetic ablation of the small GTPase Rhoa in …

Background Central nervous system levels of tumor necrosis factor‐alpha (TNF‐α), a pro-
inflammatory cytokine, regulate the neuroinflammatory response and may play a role in age …