The prion paradigm has emerged as a unifying molecular principle for the pathogenesis of
many age-related neurodegenerative diseases. This paradigm holds that a fundamental …

The misfolding and aggregation of specific proteins is a seminal occurrence in a remarkable
variety of neurodegenerative disorders. In Alzheimer disease (the most prevalent cerebral …

Currently available evidence strongly supports the position that the initiating event in
Alzheimer's disease (AD) is related to abnormal processing of β-amyloid (Aβ) peptide …

The molecular architecture of amyloids formed in vivo can be interrogated using luminescent
conjugated oligothiophenes (LCOs), a unique class of amyloid dyes. When bound to …

Age-related neurodegenerative diseases are largely limited to humans and rarely occur
spontaneously in animals. Genetically engineered mouse models recapitulate aspects of the …

Objective: To compare the diagnostic performance of PET with the amyloid ligand Pittsburgh
compound B (PiB-PET) to fluorodeoxyglucose (FDG-PET) in discriminating between …

Objective To evaluate the performance characteristics of florbetapir F18 positron emission
tomography (PET) in patients with Alzheimer's disease (AD), mild cognitive impairment …

Objective: Both amyloid‐β (Aβ) deposition and brain atrophy are associated with Alzheimer's
disease (AD) and the disease process likely begins many years before symptoms appear …

The accumulation of misfolded proteins (MP s), both unique and common, for different
diseases is central for many chronic degenerative diseases. In certain patients, MP …

Patients with early age-of-onset Alzheimer's disease show more rapid progression, more
generalized cognitive deficits and greater cortical atrophy and hypometabolism compared to …