Clinical diagnosis of Alzheimer's disease: recommendations of the International Working Group
Summary In 2018, the US National Institute on Aging and the Alzheimer's Association
proposed a purely biological definition of Alzheimer's disease that relies on biomarkers …
proposed a purely biological definition of Alzheimer's disease that relies on biomarkers …
Copper and zinc dysregulation in Alzheimer's disease
Alzheimer's disease (AD) is one of the most common forms of dementia. Despite a wealth of
knowledge on the molecular mechanisms involved in AD, current treatments have mainly …
knowledge on the molecular mechanisms involved in AD, current treatments have mainly …
Combination of plasma amyloid beta(1-42/1-40) and glial fibrillary acidic protein strongly associates with cerebral amyloid pathology
IMW Verberk, E Thijssen, J Koelewijn, K Mauroo… - Alzheimer's research & …, 2020 - Springer
Background Blood-based biomarkers for Alzheimer's disease (AD) might facilitate
identification of participants for clinical trials targeting amyloid beta (Abeta) accumulation …
identification of participants for clinical trials targeting amyloid beta (Abeta) accumulation …
Plasma β-amyloid in Alzheimer's disease and vascular disease
S Janelidze, E Stomrud, S Palmqvist, H Zetterberg… - Scientific reports, 2016 - nature.com
Implementation of amyloid biomarkers in clinical practice would be accelerated if such
biomarkers could be measured in blood. We analyzed plasma levels of Aβ42 and Aβ40 in a …
biomarkers could be measured in blood. We analyzed plasma levels of Aβ42 and Aβ40 in a …
Plasma amyloid as prescreener for the earliest A lzheimer pathological changes
IMW Verberk, RE Slot, SCJ Verfaillie… - Annals of …, 2018 - Wiley Online Library
Objective We investigated the association of plasma amyloid beta (Abeta) 40, Abeta42, and
total tau (tTau) with the presence of Alzheimer pathological changes in cognitively normal …
total tau (tTau) with the presence of Alzheimer pathological changes in cognitively normal …
Dysregulation of the epigenetic landscape of normal aging in Alzheimer's disease
Aging is the strongest risk factor for Alzheimer's disease (AD), although the underlying
mechanisms remain unclear. The chromatin state, in particular through the mark H4K16ac …
mechanisms remain unclear. The chromatin state, in particular through the mark H4K16ac …
Sex-specific association of apolipoprotein E with cerebrospinal fluid levels of tau
Importance The strongest genetic risk factor for Alzheimer disease (AD), the apolipoprotein
E (APOE) gene, has a stronger association among women compared with men. Yet limited …
E (APOE) gene, has a stronger association among women compared with men. Yet limited …
[HTML][HTML] Appropriate use criteria for lumbar puncture and cerebrospinal fluid testing in the diagnosis of Alzheimer's disease
Abstract Introduction The Alzheimer's Association convened a multidisciplinary workgroup to
develop appropriate use criteria to guide the safe and optimal use of the lumbar puncture …
develop appropriate use criteria to guide the safe and optimal use of the lumbar puncture …
Plasma phospho-tau181 in presymptomatic and symptomatic familial Alzheimer's disease: a longitudinal cohort study
Blood biomarkers have great potential to advance clinical care and accelerate trials in
Alzheimer's disease (AD). Plasma phospho-tau181 (p-tau181) is a promising blood …
Alzheimer's disease (AD). Plasma phospho-tau181 (p-tau181) is a promising blood …
Comparing plasma phospho tau, total tau, and phospho tau–total tau ratio as acute and chronic traumatic brain injury biomarkers
R Rubenstein, B Chang, JK Yue, A Chiu… - JAMA …, 2017 - jamanetwork.com
Importance Annually in the United States, at least 3.5 million people seek medical attention
for traumatic brain injury (TBI). The development of therapies for TBI is limited by the …
for traumatic brain injury (TBI). The development of therapies for TBI is limited by the …