Cancer cells undergo considerable metabolic changes to foster uncontrolled proliferation in
a hostile environment characterized by nutrient deprivation, poor vascularization and …

Introduction In physiological concentrations, heme is nontoxic to the cell and is essential for
cell survival and proliferation. Increasing intracellular heme concentrations beyond normal …

Labile heme (LH) is a complex of Fe (II) and protoporphyrin IX, an essential signaling
molecule in various biological systems. Most of the subcellular dynamics of LH remain …

Anthracyclines such as doxorubicin (Dox) are effective chemotherapies, but their use is
limited by cardiac toxicity. We hypothesized that plasma proteomics in women with breast …

Low-dose carbon monoxide (CO) is under investigation in clinical trials to treat non-
cancerous diseases and has an excellent safety profile. Due to early detection and cancer …

Colorectal carcinoma (CRC) is one of the most prevalent malignant tumors worldwide.
Meanwhile, the majority of CRC related deaths results from liver metastasis. Gene …

At inflammatory sites, cytotoxic agents are released and generated from invading immune
cells and damaged tissue cells. The further fate of the inflammation highly depends on the …

Hemopexin is the plasma protein with the highest affinity for heme. Seminal studies have
highlighted its role in different kinds of heme-associated disorders, but its implication in …

Ferroptosis is a novel form of regulated cell death trigged by various biological processes,
and p53 is involved in different ferroptosis regulations and functions as a crucial regulator …

All cancer cells reprogram metabolism to support aberrant growth. Here, we report that
cancer cells employ and depend on imbalanced and dynamic heme metabolic pathways, to …