During embryogenesis, the musculoskeletal system develops while containing within itself a
force generator in the form of the musculature. This generator becomes functional relatively …

Congruent, low-friction relative movement between the articulating elements of a synovial
joint is an essential pre-requisite for sustained, efficient, function. Where disorders of joint …

In humans, mutations in the PIEZO2 gene, which encodes for a mechanosensitive ion
channel, were found to result in skeletal abnormalities including scoliosis and hip dysplasia …

Skeletal shape depends on the transmission of contractile muscle forces from tendon to
bone across the enthesis. Loss of muscle loading impairs enthesis development, yet little is …

Developmental dysplasia of the hip (DDH) in humans is a common condition that is
associated with hip pain, functional limitations, and secondary osteoarthritis (OA). Surgical …

Fetal movements are essential for normal development of the human skeleton. When fetal
movements are reduced or restricted, infants are at higher risk of developmental dysplasia of …

Infant positioning in daily life may affect hip development. While neonatal animal studies
indicate detrimental relationships between inactive lower extremities and hip development …

Defects in articular cartilage injury and chronic osteoarthritis are very widespread and
common, and the ability of injured cartilage to repair itself is limited. Stem cell-based …

Hip dysplasia (HD) is common in both humans and dogs. This interconnection is because
humans and dogs descended from a common ancestor and therefore have a similar …

Although osteoarthritis (OA) in the hip joint is a common and debilitating degenerative
disease, the precise molecular mechanisms underlying its pathological process remains …