The pituitary gland is a central endocrine organ regulating basic physiological functions,
including growth, the stress response, reproduction, metabolic homeostasis, and lactation …

The sine oculis homeobox (SIX) protein family is a group of evolutionarily conserved
transcription factors that are found in diverse organisms that range from flatworms to …

Enhanced neovasculogenesis, especially vasculogenic mimicry (VM), contributes to the
development of triple-negative breast cancer (TNBC). Breast tumor-initiating cells (BTICs) …

Abstract The Eyes Absent (EYA) proteins, first described in the context of fly eye
development, are now implicated in processes as disparate as organ development, innate …

Six1 is a critical regulator of embryonic development that requires interaction with the Eya
family of proteins (Eya1-4) to activate the transcription of genes involved in neurogenesis …

Precise regulation of gene expression is crucial to myogenesis and is thought to require the
cooperation of various transcription factors. On the basis of a bioinformatic analysis of gene …

Branchio‐oto‐renal syndrome, a phenotype consisting of hearing loss, auricular
malformations, branchial arch remnants, and renal anomalies is now recognized as one of …

Integration of multiple signaling pathways at the level of their transcriptional effectors
provides an important strategy for fine-tuning gene expression and ensuring a proper …

In the past two decades, many studies have shown that sine oculis homeobox 1 (Six1) is a
powerful regulator of organogenesis and disease, with important roles in tumorigenesis; …

Single-nucleotide mutations in human SIX1 result in amino acid substitutions in either the
protein-protein interaction domain or the homeodomain, and cause∼ 4% of branchio-otic …