Pyridazinone: an important element of pharmacophore possessing broad spectrum of activity
S Dubey, PA Bhosle - Medicinal Chemistry Research, 2015 - Springer
In the last few years, the pyridazine derivatives have been found to exhibit a wide range of
pharmacological activities. A large number of research articles and patents described them …
pharmacological activities. A large number of research articles and patents described them …
Pyridazinone: an attractive lead for anti-inflammatory and analgesic drug discovery
In spite of the availability of a large number of anti-inflammatory and analgesic agents,
fighting pain and inflammation remains a common problem. The current review article …
fighting pain and inflammation remains a common problem. The current review article …
N-Heterocyclic carbene-promoted [4+ 2] annulation of α-chloro hydrazones with α-chloro aliphatic aldehydes to access enantioenriched dihydropyridazinones
Y Zhou, H Zhou, J Xu - The Journal of Organic Chemistry, 2022 - ACS Publications
An expeditious protocol for the assembly of chiral 4, 5-dihydropyridazin-3 (2 H)-ones from α-
chloro hydrazones and α-chloro aliphatic aldehydes via N-heterocyclic carbene (NHC) …
chloro hydrazones and α-chloro aliphatic aldehydes via N-heterocyclic carbene (NHC) …
Synthesis, in-vitro evaluation, molecular docking, and kinetic studies of pyridazine-triazole hybrid system as novel α-glucosidase inhibitors
S Moghimi, S Salarinejad, M Toolabi, L Firoozpour… - Bioorganic …, 2021 - Elsevier
In this study, we reported the discovery of pyridazine based 1, 2, 3-triazole derivatives as
inhibitors of α-glucosidase. All target compounds exhibited significant inhibitory activities …
inhibitors of α-glucosidase. All target compounds exhibited significant inhibitory activities …
Experimental and computational approaches for solubility measurement of pyridazinone derivative in binary (DMSO+ water) systems
The current research work was performed to evaluate the solubilization behavior, solution
thermodynamics, and solvation behavior of poorly soluble pyridazinone derivative ie, 6 …
thermodynamics, and solvation behavior of poorly soluble pyridazinone derivative ie, 6 …
New pyridazine derivatives as selective COX-2 inhibitors and potential anti-inflammatory agents; design, synthesis and biological evaluation
New pyridazinone and pyridazinthione derivatives were designed, synthesized and
identified through performing 1 H NMR, 13 C NMR, IR and MS spectroscopic techniques. All …
identified through performing 1 H NMR, 13 C NMR, IR and MS spectroscopic techniques. All …
Carbene-catalyzed enantioselective annulation of dinucleophilic hydrazones and bromoenals for access to aryl-dihydropyridazinones and related drugs
4, 5-Dihydropyridazinones bearing an aryl substituent at the C6-position are important motifs
in drug molecules. Herein, we developed an efficient protocol to access aryl …
in drug molecules. Herein, we developed an efficient protocol to access aryl …
Synthesis, Characterization and Solubility Determination of 6-Phenyl-pyridazin-3(2H)-one in Different Pharmaceutical Solvents
The current research work proposed the solubility data and solution thermodynamic
properties of the cardiovascular agent 6-phenylpyridazin-3 (2 H)-one [PPD] in twelve …
properties of the cardiovascular agent 6-phenylpyridazin-3 (2 H)-one [PPD] in twelve …
Cytotoxicity of new pyridazin‐3(2H)‐one derivatives orchestrating oxidative stress in human triple‐negative breast cancer (MDA‐MB‐468)
N Bouchmaa, R Ben Mrid, Y Boukharsa… - Archiv der …, 2018 - Wiley Online Library
Triple‐negative breast cancer (TNBC) is a complex and aggressive subtype of breast cancer
characterized by high morbidity and mortality. In the absence of targeted therapy, only …
characterized by high morbidity and mortality. In the absence of targeted therapy, only …
Solubility and thermodynamic/solvation behavior of 6-phenyl-4, 5-dihydropyridazin-3 (2H)-one in different (Transcutol+ water) mixtures
Pyridazinone derivatives are useful cardiovascular drugs which suffer from weak aqueous
solubility and toxicity problems. Hence, in this work, the solubility of pyridazinone derivative …
solubility and toxicity problems. Hence, in this work, the solubility of pyridazinone derivative …