Targeting interferon-γ in hyperinflammation: opportunities and challenges
F De Benedetti, G Prencipe, C Bracaglia… - Nature Reviews …, 2021 - nature.com
Interferon-γ (IFNγ) is a pleiotropic cytokine with multiple effects on the inflammatory
response and on innate and adaptive immunity. Overproduction of IFNγ underlies several …
response and on innate and adaptive immunity. Overproduction of IFNγ underlies several …
An integrated view of humoral innate immunity: pentraxins as a paradigm
B Bottazzi, A Doni, C Garlanda… - Annual review of …, 2009 - annualreviews.org
The innate immune system consists of a cellular and a humoral arm. Pentraxins (eg, the
short pentraxin C reactive protein and the long pentraxin PTX3) are key components of the …
short pentraxin C reactive protein and the long pentraxin PTX3) are key components of the …
Recognition and inhibition of SARS-CoV-2 by humoral innate immunity pattern recognition molecules
The humoral arm of innate immunity includes diverse molecules with antibody-like functions,
some of which serve as disease severity biomarkers in coronavirus disease 2019 (COVID …
some of which serve as disease severity biomarkers in coronavirus disease 2019 (COVID …
PTX3, a humoral pattern recognition molecule, in innate immunity, tissue repair, and cancer
C Garlanda, B Bottazzi, E Magrini… - Physiological …, 2018 - journals.physiology.org
Innate immunity includes a cellular and a humoral arm. PTX3 is a fluid-phase pattern
recognition molecule conserved in evolution which acts as a key component of humoral …
recognition molecule conserved in evolution which acts as a key component of humoral …
Genetic PTX3 deficiency and aspergillosis in stem-cell transplantation
C Cunha, F Aversa, JF Lacerda, A Busca… - … England Journal of …, 2014 - Mass Medical Soc
Background The soluble pattern-recognition receptor known as long pentraxin 3 (PTX3) has
a nonredundant role in antifungal immunity. The contribution of single-nucleotide …
a nonredundant role in antifungal immunity. The contribution of single-nucleotide …
[PDF][PDF] HDL in infectious diseases and sepsis
During infection significant alterations in lipid metabolism and lipoprotein composition occur.
Triglyceride and VLDL cholesterol levels increase, while reduced HDL cholesterol (HDL-C) …
Triglyceride and VLDL cholesterol levels increase, while reduced HDL cholesterol (HDL-C) …
Pentraxins in innate immunity: from C-reactive protein to the long pentraxin PTX3
Pentraxins are a family of multimeric pattern-recognition proteins highly conserved in
evolution. Based on the primary structure of the subunit, the pentraxins are divided into two …
evolution. Based on the primary structure of the subunit, the pentraxins are divided into two …
Selective predisposition to bacterial infections in IRAK-4–deficient children: IRAK-4–dependent TLRs are otherwise redundant in protective immunity
Human interleukin (IL) 1 receptor–associated kinase 4 (IRAK-4) deficiency is a recently
discovered primary immunodeficiency that impairs Toll/IL-1R immunity, except for the Toll …
discovered primary immunodeficiency that impairs Toll/IL-1R immunity, except for the Toll …
The long pentraxin PTX3 as a humoral innate immunity functional player and biomarker of infections and sepsis
The first line of defense in innate immunity is provided by cellular and humoral mediators.
Pentraxins are a superfamily of phylogenetically conserved humoral mediators of innate …
Pentraxins are a superfamily of phylogenetically conserved humoral mediators of innate …
Role of complement and Fcγ receptors in the protective activity of the long pentraxin PTX3 against Aspergillus fumigatus
Abstract Pentraxin 3 (PTX3) is a soluble pattern recognition molecule playing a
nonredundant role in resistance against Aspergillus fumigatus. The present study was …
nonredundant role in resistance against Aspergillus fumigatus. The present study was …