[HTML][HTML] Spindle assembly checkpoint activation and silencing at kinetochores
The spindle assembly checkpoint (SAC) is a surveillance mechanism that promotes
accurate chromosome segregation in mitosis. The checkpoint senses the attachment state of …
accurate chromosome segregation in mitosis. The checkpoint senses the attachment state of …
Evolutionary dynamics of the spindle assembly checkpoint in eukaryotes
The tremendous diversity in eukaryotic life forms can ultimately be traced back to
evolutionary modifications at the level of molecular networks. Deep understanding of these …
evolutionary modifications at the level of molecular networks. Deep understanding of these …
CDC20 assists its catalytic incorporation in the mitotic checkpoint complex
Open (O) and closed (C) topologies of HORMA-domain proteins are respectively associated
with inactive and active states of fundamental cellular pathways. The HORMA protein O …
with inactive and active states of fundamental cellular pathways. The HORMA protein O …
BUB1 drives the occurrence and development of bladder cancer by mediating the STAT3 signaling pathway
N Jiang, Y Liao, M Wang, Y Wang, K Wang… - Journal of Experimental …, 2021 - Springer
Background The incidence of bladder urothelial carcinoma (UC), a common malignancy of
the urinary tract, is approximately three times higher in men than in women. High expression …
the urinary tract, is approximately three times higher in men than in women. High expression …
Untangling the contribution of Haspin and Bub1 to Aurora B function during mitosis
MA Hadders, S Hindriksen, MA Truong… - Journal of Cell …, 2020 - rupress.org
Aurora B kinase is essential for faithful chromosome segregation during mitosis. During (pro)
metaphase, Aurora B is concentrated at the inner centromere by the kinases Haspin and …
metaphase, Aurora B is concentrated at the inner centromere by the kinases Haspin and …
[HTML][HTML] Microtubule nucleation from the fibrous corona by LIC1-pericentrin promotes chromosome congression
Error-free chromosome segregation in mitosis and meiosis relies on the assembly of a
microtubule-based spindle that interacts with kinetochores to guide chromosomes to the cell …
microtubule-based spindle that interacts with kinetochores to guide chromosomes to the cell …
Dynein at the kinetochore
R Gassmann - Journal of cell science, 2023 - journals.biologists.com
The microtubule minus-end-directed motility of cytoplasmic dynein 1 (dynein), arguably the
most complex and versatile cytoskeletal motor, is harnessed for diverse functions, such as …
most complex and versatile cytoskeletal motor, is harnessed for diverse functions, such as …
Chemogenetic profiling reveals PP2A‐independent cytotoxicity of proposed PP2A activators iHAP1 and DT‐061
G Vit, J Duro, G Rajendraprasad, EPT Hertz… - The EMBO …, 2022 - embopress.org
Abstract Protein phosphatase 2A (PP2A) is an abundant phosphoprotein phosphatase that
acts as a tumor suppressor. For this reason, compounds able to activate PP2A are attractive …
acts as a tumor suppressor. For this reason, compounds able to activate PP2A are attractive …
Juxtaposition of Bub1 and Cdc20 on phosphorylated Mad1 during catalytic mitotic checkpoint complex assembly
In response to improper kinetochore-microtubule attachments in mitosis, the spindle
assembly checkpoint (SAC) assembles the mitotic checkpoint complex (MCC) to inhibit the …
assembly checkpoint (SAC) assembles the mitotic checkpoint complex (MCC) to inhibit the …
[HTML][HTML] Functional genomics for cancer drug target discovery
B Haley, F Roudnicky - Cancer Cell, 2020 - cell.com
Functional genomics describes a field of biology that uses a range of approaches for
assessing gene function with high-throughput molecular, genetic, and cellular technologies …
assessing gene function with high-throughput molecular, genetic, and cellular technologies …