High spatial resolution mass spectrometry imaging for spatial metabolomics: Advances, challenges, and future perspectives

S Ma, Y Leng, X Li, Y Meng, Z Yin, W Hang - TrAC Trends in Analytical …, 2023 - Elsevier
Spatial metabolomics is an emerging field of omics research that has enabled localizing
small molecules in tissues and cells. Mass spectrometry imaging (MSI) technologies allow …

Analysis of carbohydrates and glycoconjugates by matrix‐assisted laser desorption/ionization mass spectrometry: An update for 2019–2020

DJ Harvey - Mass Spectrometry Reviews, 2023 - Wiley Online Library
This review is the tenth update of the original article published in 1999 on the application of
matrix‐assisted laser desorption/ionization (MALDI) mass spectrometry to the analysis of …

MALDI-2 for the Enhanced Analysis of N-Linked Glycans by Mass Spectrometry Imaging

B Heijs, A Potthoff, J Soltwisch… - Analytical chemistry, 2020 - ACS Publications
N-glycans are important players in a variety of pathologies including different types of
cancer,(auto) immune diseases, and also viral infections. Matrix-assisted laser …

Evaluation of 6 MALDI-matrices for 10 μm lipid imaging and on-tissue MSn with AP-MALDI-Orbitrap

TB Angerer, J Bour, JL Biagi… - Journal of the …, 2022 - ACS Publications
Mass spectrometry imaging is a technique uniquely suited to localize and identify lipids in a
tissue sample. Using an atmospheric pressure (AP-) matrix-assisted laser desorption …

Mass spectrometry imaging of lipids using MALDI coupled with plasma-based post-ionization on a trapped ion mobility mass spectrometer

JA Michael, SM Mutuku, B Ucur, T Sarretto… - Analytical …, 2022 - ACS Publications
Here we report the development and optimization of a mass spectrometry imaging (MSI)
platform that combines an atmospheric-pressure matrix-assisted laser desorption/ionization …

Atmospheric pressure MALDI mass spectrometry imaging using in-line plasma induced postionization

EA Elia, M Niehaus, RT Steven, JC Wolf… - Analytical …, 2020 - ACS Publications
Atmospheric pressure ionization methods confer a number of advantages over more
traditional vacuum based techniques, in particular ease of hyphenation to a range of mass …

Novel technical developments in mass spectrometry imaging in 2020: A mini review

BA Dilmetz, YR Lee, MR Condina… - Analytical Science …, 2021 - Wiley Online Library
The applicability of mass spectrometry imaging (MSI) has exponentially increased with the
improvement of sample preparation, instrumentation (spatial resolution) and data analysis …

Enhanced MALDI-2 Sensitivity with Reflecting Post-Ionization Laser for High-Resolution MS Imaging Combined with Real-Time Microscope Imaging

Z Geng, Q Jin, L Liu, Y Huang, X Zhou… - Analytical …, 2024 - ACS Publications
Laser-induced matrix-assisted laser desorption/ionization post-ionization (MALDI-2) could
improve the MALDI sensitivity of biological metabolites by over 1 order of magnitude. Herein …

MALDI-2 Mass Spectrometry for Synthetic Polymer Analysis

L Molina-Millán, A Körber, B Flinders… - …, 2023 - ACS Publications
Synthetic polymers are ubiquitous in daily life, and their properties offer diverse benefits in
numerous applications. However, synthetic polymers also present an increasing …

High-Specificity Imaging Mass Spectrometry

ME Colley, AB Esselman, CF Scott… - Annual Review of …, 2024 - annualreviews.org
Imaging mass spectrometry (IMS) enables highly multiplexed, untargeted tissue mapping for
a broad range of molecular classes, facilitating in situ biological discovery. Yet, challenges …