Delivery of therapeutics to the inner ear: The challenge of the blood-labyrinth barrier
S Nyberg, NJ Abbott, X Shi, PS Steyger… - Science translational …, 2019 - science.org
Permanent hearing loss affects more than 5% of the world's population, yet there are no
nondevice therapies that can protect or restore hearing. Delivery of therapeutics to the …
nondevice therapies that can protect or restore hearing. Delivery of therapeutics to the …
Forcing cells to change lineages
T Graf, T Enver - Nature, 2009 - nature.com
The ability to produce stem cells by induced pluripotency (iPS reprogramming) has
rekindled an interest in earlier studies showing that transcription factors can directly convert …
rekindled an interest in earlier studies showing that transcription factors can directly convert …
[HTML][HTML] Notch inhibition induces cochlear hair cell regeneration and recovery of hearing after acoustic trauma
Hearing loss due to damage to auditory hair cells is normally irreversible because
mammalian hair cells do not regenerate. Here, we show that new hair cells can be induced …
mammalian hair cells do not regenerate. Here, we show that new hair cells can be induced …
[HTML][HTML] Mechanotransduction by hair cells: models, molecules, and mechanisms
PG Gillespie, U Müller - Cell, 2009 - cell.com
Mechanotransduction, the transformation of mechanical force into an electrical signal, allows
living organisms to hear, register movement and gravity, detect touch, and sense changes in …
living organisms to hear, register movement and gravity, detect touch, and sense changes in …
[HTML][HTML] Inner ear gene therapies take off: current promises and future challenges
S Delmaghani, A El-Amraoui - Journal of clinical medicine, 2020 - mdpi.com
Hearing impairment is the most frequent sensory deficit in humans of all age groups, from
children (1/500) to the elderly (more than 50% of the over-75 s). Over 50% of congenital …
children (1/500) to the elderly (more than 50% of the over-75 s). Over 50% of congenital …
[HTML][HTML] Single-cell transcriptome analysis reveals three sequential phases of gene expression during zebrafish sensory hair cell regeneration
Loss of sensory hair cells (HCs) in the mammalian inner ear leads to permanent hearing
and vestibular defects, whereas loss of HCs in zebrafish results in their regeneration. We …
and vestibular defects, whereas loss of HCs in zebrafish results in their regeneration. We …
New treatment options for hearing loss
U Müller, PG Barr-Gillespie - Nature reviews Drug discovery, 2015 - nature.com
Hearing loss is the most common form of sensory impairment in humans and affects more
than 40 million people in the United States alone. No drug-based therapy has been …
than 40 million people in the United States alone. No drug-based therapy has been …
Progress in gene therapy for neurological disorders
Diseases of the nervous system have devastating effects and are widely distributed among
the population, being especially prevalent in the elderly. These diseases are often caused …
the population, being especially prevalent in the elderly. These diseases are often caused …
Sound strategies for hearing restoration
GSG Géléoc, JR Holt - Science, 2014 - science.org
Background Sensorineural hearing loss is the most common sensory deficit in the world,
with nearly 300 million affected individuals. The problem is multifactorial and can arise from …
with nearly 300 million affected individuals. The problem is multifactorial and can arise from …
Age-dependent in vivo conversion of mouse cochlear pillar and Deiters' cells to immature hair cells by Atoh1 ectopic expression
Z Liu, JA Dearman, BC Cox, BJ Walters… - Journal of …, 2012 - Soc Neuroscience
Unlike nonmammalian vertebrates, mammals cannot convert inner ear cochlear supporting
cells (SCs) into sensory hair cells (HCs) after damage, thus causing permanent deafness …
cells (SCs) into sensory hair cells (HCs) after damage, thus causing permanent deafness …