Permanent hearing loss affects more than 5% of the world's population, yet there are no
nondevice therapies that can protect or restore hearing. Delivery of therapeutics to the …

The ability to produce stem cells by induced pluripotency (iPS reprogramming) has
rekindled an interest in earlier studies showing that transcription factors can directly convert …

Hearing loss due to damage to auditory hair cells is normally irreversible because
mammalian hair cells do not regenerate. Here, we show that new hair cells can be induced …

Mechanotransduction, the transformation of mechanical force into an electrical signal, allows
living organisms to hear, register movement and gravity, detect touch, and sense changes in …

Hearing impairment is the most frequent sensory deficit in humans of all age groups, from
children (1/500) to the elderly (more than 50% of the over-75 s). Over 50% of congenital …

Loss of sensory hair cells (HCs) in the mammalian inner ear leads to permanent hearing
and vestibular defects, whereas loss of HCs in zebrafish results in their regeneration. We …

Hearing loss is the most common form of sensory impairment in humans and affects more
than 40 million people in the United States alone. No drug-based therapy has been …

Diseases of the nervous system have devastating effects and are widely distributed among
the population, being especially prevalent in the elderly. These diseases are often caused …

Background Sensorineural hearing loss is the most common sensory deficit in the world,
with nearly 300 million affected individuals. The problem is multifactorial and can arise from …

Unlike nonmammalian vertebrates, mammals cannot convert inner ear cochlear supporting
cells (SCs) into sensory hair cells (HCs) after damage, thus causing permanent deafness …