Cyclin-dependent kinase 8 (CDK8) plays a vital role in regulating transcription either
through its association with the Mediator complex or by phosphorylating transcription factors …

The discovery that Notch activation involves a proteolytic cleavage to release the
intracellular domain (NICD) revolutionized the field of Notch signaling. It resulted in a simple …

The developmentally indispensable Notch pathway exhibits a high grade of pleiotropism in
its biological output. Emerging evidence supports the notion of post-translational …

Major signaling pathways, such as Notch, Hedgehog (Hh), Wnt/β-catenin and Hippo, are
targeted by a plethora of physiological and pathological stimuli, ultimately resulting in the …

CDK8 is an important member of the cyclin-dependent kinase family associated with
transcription and acts as a key “molecular switch” in the Mediator complex. CDK8 regulates …

Background Epithelial-mesenchymal transition (EMT) has a fundamental role in tumor
initiation, progression, and metastasis. Helicobacter pylori (HP) induces EMT and thus …

The current study aimed to explore the functions and roles of microRNA‐193b (miR‐193b) in
the myocardium with ischemia‐reperfusion (I/R) injury and a potential therapeutic method for …

Notch exerts important functions in cell proliferation, survival, and differentiation, which plays
a critical role in tumor development when aberrantly activated. Mastermind‐like protein 1 …

A major goal of medicinal chemists is to identify and validate novel and effective kinase
targets for treatment of cancer. Recent studies have shown that cyclin-dependent kinase 8 …

Background: Ovarian cancer is the fifth leading cause of cancer-related deaths among
women globally. Cancer stem cells (CSCs) are a subpopulation of tumor cells involved in …