The human major histocompatibility complex is a family of genes that encodes HLAs, which
have a crucial role in defence against foreign pathogens and immune surveillance of …

Almost every experimental treatment strategy using non-autologous cell, tissue or organ
transplantation is tested in small and large animal models before clinical translation …

Islet transplantation to treat insulin-dependent diabetes is greatly limited by the need for
maintenance immunosuppression. We report a strategy through which cotransplantation of …

Five patients with end-stage renal disease received combined bone marrow and kidney
transplants from HLA single-haplotype mismatched living related donors, with the use of a …

We report here the long-term results of HLA-mismatched kidney transplantation without
maintenance immunosuppression (IS) in 10 subjects following combined kidney and bone …

Many strategies have been proposed to induce tolerance to transplanted tissue in rodents;
however, few if any have shown equal efficacy when tested in nonhuman primate transplant …

To the Editor: We previously reported results of our study of combined kidney and bone
marrow transplantation without maintenance immunosuppression. We extended the study to …

The recent recognition that antibody-mediated rejection (ABMR) is the major cause of kidney
transplant loss creates strong interest in its pathogenesis. We used microarray analysis of …

Memory T cells are characterized by their low activation threshold, robust effector functions,
and resistance to conventional immunosuppression and costimulation blockade. Unlike their …

“Mixed chimerism” refers to a state in which the lymphohematopoietic system of the recipient
of allogeneic hematopoietic stem cells comprises a mixture of host and donor cells. This …