The methylation of histone H3 at lysine 36 (H3K36me) is essential for maintaining genomic
stability. Indeed, this methylation mark is essential for proper transcription, recombination …

Abstract NSD1, NSD2, and NSD3 constitute the nuclear receptor-binding SET Domain
(NSD) family of histone 3 lysine 36 (H3K36) methyltransferases. These structurally similar …

The NSD (nuclear receptor SET domain-containing) family of histone lysine
methyltransferases is a critical participant in chromatin integrity as evidenced by the number …

The Sotos syndrome gene product, NSD1, is a SET domain histone methyltransferase that
primarily dimethylates nucleosomal histone H3 lysine 36 (H3K36). To date, the intrinsic …

Abstract Purpose: Multiple myeloma SET (Suppressor of variegation, Enhancer of zeste, and
Trithorax) domain (MMSET) is a histone lysine methyltransferase deregulated in a subgroup …

Deciphering cell-intrinsic mechanisms of metastasis progression in vivo is essential to
identify novel therapeutic approaches. Here we elucidate cell-intrinsic drivers of metastatic …

Histone modifications are key factors in chromatin packaging, and are responsible for gene
regulation during cell fate determination and development. Abnormal alterations in histone …

Colorectal cancer (CRC) is the second common cause of cancer-related human mortalities.
Dysregulation of histone 3 (H3) methylation could lead to transcriptional activation of …

Melanoma is the deadliest form of skin cancer, affecting men more frequently and severely
than women. Although recent studies suggest that differences in activity of the androgen …

Androgen receptor (AR) is a ligand-responsive transcription factor that drives terminal
differentiation of the prostatic luminal epithelia. By contrast, in tumors originating from these …