Exploring the expanding universe of small RNAs
The world of small noncoding RNAs (sncRNAs) is ever-expanding, from small interfering
RNA, microRNA and Piwi-interacting RNA to the recently emerging non-canonical sncRNAs …
RNA, microRNA and Piwi-interacting RNA to the recently emerging non-canonical sncRNAs …
On the expanding roles of tRNA fragments in modulating cell behavior
R Magee, I Rigoutsos - Nucleic acids research, 2020 - academic.oup.com
The fragments that derive from transfer RNAs (tRNAs) are an emerging category of
regulatory RNAs. Known as tRFs, these fragments were reported for the first time only a …
regulatory RNAs. Known as tRFs, these fragments were reported for the first time only a …
Seizure diaries and forecasting with wearables: epilepsy monitoring outside the clinic
It is a major challenge in clinical epilepsy to diagnose and treat a disease characterized by
infrequent seizures based on patient or caregiver reports and limited duration clinical …
infrequent seizures based on patient or caregiver reports and limited duration clinical …
Roles and regulation of tRNA-derived small RNAs in animals
S Muthukumar, CT Li, RJ Liu, C Bellodi - Nature Reviews Molecular Cell …, 2024 - nature.com
A growing class of small RNAs, known as tRNA-derived RNAs (tdRs), tRNA-derived small
RNAs or tRNA-derived fragments, have long been considered mere intermediates of tRNA …
RNAs or tRNA-derived fragments, have long been considered mere intermediates of tRNA …
tRNA renovatio: rebirth through fragmentation
B Kuhle, Q Chen, P Schimmel - Molecular Cell, 2023 - cell.com
Summary tRNA function is based on unique structures that enable mRNA decoding using
anticodon trinucleotides. These structures interact with specific aminoacyl-tRNA synthetases …
anticodon trinucleotides. These structures interact with specific aminoacyl-tRNA synthetases …
5′-tRF-GlyGCC: a tRNA-derived small RNA as a novel biomarker for colorectal cancer diagnosis
Y Wu, X Yang, G Jiang, H Zhang, L Ge, F Chen, J Li… - Genome medicine, 2021 - Springer
Background tRNA-derived small RNAs (tDRs), which are widely distributed in human tissues
including blood and urine, play an important role in the progression of cancer. However, the …
including blood and urine, play an important role in the progression of cancer. However, the …
Precise detection of low-level somatic mutation in resected epilepsy brain tissue
Low-level somatic mutations have been shown to be the major genetic etiology of intractable
epilepsy. The extents thereof, however, have yet to be systematically and accurately …
epilepsy. The extents thereof, however, have yet to be systematically and accurately …
Identification of clinically relevant biomarkers of epileptogenesis—a strategic roadmap
M Simonato, DV Agoston, A Brooks-Kayal… - Nature Reviews …, 2021 - nature.com
Onset of many forms of epilepsy occurs after an initial epileptogenic insult or as a result of an
identified genetic defect. Given that the precipitating insult is known, these epilepsies are, in …
identified genetic defect. Given that the precipitating insult is known, these epilepsies are, in …
Transfer RNAs: diversity in form and function
As the adaptor that decodes mRNA sequence into protein, the basic aspects of tRNA
structure and function are central to all studies of biology. Yet the complexities of their …
structure and function are central to all studies of biology. Yet the complexities of their …
tsRNAs: Novel small molecules from cell function and regulatory mechanism to therapeutic targets
T Zong, Y Yang, H Zhao, L Li, M Liu, X Fu… - Cell …, 2021 - Wiley Online Library
Abstract tsRNAs are small fragments of RNAs with specific lengths that are generated by
particular ribonucleases, such as dicer and angiogenin (ANG), clipping on the rings of …
particular ribonucleases, such as dicer and angiogenin (ANG), clipping on the rings of …