The physiology, pathology, and pharmacology of voltage-gated calcium channels and their future therapeutic potential

GW Zamponi, J Striessnig, A Koschak… - Pharmacological …, 2015 - Elsevier
Voltage-gated calcium channels are required for many key functions in the body. In this
review, the different subtypes of voltage-gated calcium channels are described and their …

Neuronal voltage-gated calcium channels: structure, function, and dysfunction

BA Simms, GW Zamponi - Neuron, 2014 - cell.com
Voltage-gated calcium channels are the primary mediators of depolarization-induced
calcium entry into neurons. There is great diversity of calcium channel subtypes due to …

Cross-talk of four types of RNA modification writers defines tumor microenvironment and pharmacogenomic landscape in colorectal cancer

H Chen, J Yao, R Bao, Y Dong, T Zhang, Y Du… - Molecular cancer, 2021 - Springer
Background The four major RNA adenosine modifications, ie, m 6 A, m 1 A, alternative
polyadenylation, and adenosine-to-inosine RNA editing, are mediated mostly by the “writer” …

The ADAR protein family

YA Savva, LE Rieder, RA Reenan - Genome biology, 2012 - Springer
Adenosine to inosine (A-to-I) RNA editing is a post-transcriptional process by which
adenosines are selectively converted to inosines in double-stranded RNA (dsRNA) …

L‐type Ca2+ channels in heart and brain

J Striessnig, A Pinggera, G Kaur… - Wiley Interdisciplinary …, 2014 - Wiley Online Library
L‐type calcium channels (Cav1) represent one of the three major classes (Cav1–3) of
voltage‐gated calcium channels. They were identified as the target of clinically used calcium …

Calmodulin regulation (calmodulation) of voltage-gated calcium channels

M Ben-Johny, DT Yue - Journal of General Physiology, 2014 - rupress.org
Calmodulin regulation (calmodulation) of the family of voltage-gated CaV1-2 channels
comprises a prominent prototype for ion channel regulation, remarkable for its powerful …

[HTML][HTML] Regulation of CaV2 calcium channels by G protein coupled receptors

GW Zamponi, KPM Currie - Biochimica et Biophysica Acta (BBA) …, 2013 - Elsevier
Voltage gated calcium channels (Ca2+ channels) are key mediators of depolarization
induced calcium influx into excitable cells, and thereby play pivotal roles in a wide array of …

Adenosine-to-inosine RNA editing in neurological development and disease

Y Yang, S Okada, M Sakurai - RNA biology, 2021 - Taylor & Francis
ABSTRACT Adenosine-to-inosine (A-to-I) editing is one of the most prevalent post-
transcriptional RNA modifications in metazoan. This reaction is catalysed by enzymes called …

Extensive recoding of the neural proteome in cephalopods by RNA editing

JJC Rosenthal, E Eisenberg - Annual Review of Animal …, 2023 - annualreviews.org
The coleoid cephalopods have the largest brains, and display the most complex behaviors,
of all invertebrates. The molecular and cellular mechanisms that underlie these remarkable …

Ion channels controlling circadian rhythms in suprachiasmatic nucleus excitability

JRM Harvey, AE Plante… - Physiological …, 2020 - journals.physiology.org
Animals synchronize to the environmental day-night cycle by means of an internal circadian
clock in the brain. In mammals, this timekeeping mechanism is housed in the …