The combination of next-generation sequencing and advanced computational data analysis
approaches has revolutionized our understanding of the genomic underpinnings of cancer …

A synthetic lethal interaction occurs between two genes when the perturbation of either gene
alone is viable but the perturbation of both genes simultaneously results in the loss of …

CIViC is an expert-crowdsourced knowledgebase for Clinical Interpretation of Variants in
Cancer describing the therapeutic, prognostic, diagnostic and predisposing relevance of …

Background Recent advances are enabling delivery of precision genomic medicine to
cancer clinics. While the majority of approaches profile panels of selected genes or hotspot …

Background The clinical utility of molecular profiling of tumor tissue to guide treatment of
patients with advanced solid tumors is unknown. Our objectives were to evaluate the …

Advanced and metastatic tumors with complex treatment histories drive cancer mortality.
Here we describe the POG570 cohort, a comprehensive whole-genome, transcriptome and …

Purpose: Recent studies have identified mutation signatures of homologous recombination
deficiency (HRD) in over 20% of breast cancers, as well as pancreatic, ovarian, and gastric …

Purpose Fresh-frozen (FF) tissue is the optimal source of DNA for whole-genome
sequencing (WGS) of cancer patients. However, it is not always available, limiting the …

Background Due to rapid technical advances, steeply declining sequencing costs, and the
ever-increasing number of targeted therapies, it can be expected that extensive tumor …

Purpose: Immune checkpoint inhibitors (ICI) have revolutionized the treatment of solid
tumors with dramatic and durable responses seen across multiple tumor types. However …