Meningitis is defined as the inflammation of the meninges that is most often caused by
various bacterial and viral pathogens, and is associated with high rates of mortality and …

This review summarizes the recent Global Meningococcal Initiative (GMI) regional meeting,
which explored meningococcal disease in North America. Invasive meningococcal disease …

Addressing many of the major outstanding questions in the fields of microbial evolution and
pathogenesis will require analyses of populations of microbial genomes. Although …

Neisseria meningitidis is a common commensal bacterium found in the respiratory tract, but
it can also cause severe, invasive disease. Vaccines have been employed which have been …

In Brazil, Leishmania braziliensis is the main causative agent of the neglected tropical
disease, cutaneous leishmaniasis (CL). CL presents on a spectrum of disease severity with …

Bacterial meningitis is a major global cause of morbidity and mortality. Rapid identification of
the aetiological agent of meningitis is essential for clinical and public health management …

Introduction The epidemiology of invasive meningococcal disease (IMD), a rare but
potentially fatal illness, is typically described as unpredictable and subject to sporadic …

Bloodstream infection is a major cause of morbidity and death worldwide. Timely and
appropriate treatment can reduce mortality among critically ill patients. Current diagnostic …

Downstream next-generation sequencing (NGS) of the syphilis spirochete Treponema
pallidum subspecies pallidum (T. pallidum) is hindered by low bacterial loads and the …

High-throughput sequencing (HTS) has revolutionized microbiology, but many microbes
exist at low abundance in their natural environment and/or are difficult, if not impossible, to …