Genomic DNA is folded into loops and topologically associating domains (TADs), which
serve important structural and regulatory roles. It has been proposed that these genomic …

Many cellular processes require large-scale rearrangements of chromatin structure.
Structural maintenance of chromosomes (SMC) protein complexes are molecular machines …

Cohesin catalyses the folding of the genome into loops that are anchored by CTCF. The
molecular mechanism of how cohesin and CTCF structure the 3D genome has remained …

Topologically associating domains (TADs) are fundamental structural and functional
building blocks of human interphase chromosomes, yet the mechanisms of TAD formation …

SMC (structural maintenance of chromosomes) complexes—which include condensin,
cohesin and the SMC5–SMC6 complex—are major components of chromosomes in all …

Structural maintenance of chromosomes (SMC) complexes are key organizers of
chromosome architecture in all kingdoms of life. Despite seemingly divergent functions, such …

As a ring-shaped adenosine triphosphatase (ATPase) machine, cohesin organizes the
eukaryotic genome by extruding DNA loops and mediates sister chromatid cohesion by …

SMC protein complexes are molecular machines that provide structure to chromosomes.
These complexes bridge DNA elements and by doing so build DNA loops in cis and hold …

Structural maintenance of chromosome (SMC) complexes are proteinaceous rings that
embrace DNA to enable vital chromosomal functions. The ring is formed by two SMC …

The cohesin complex topologically encircles DNA to promote sister chromatid cohesion.
Alternatively, cohesin extrudes DNA loops, thought to reflect chromatin domain formation …