The cardiovascular system is hardwired to the brain via multilayered afferent and efferent
polysynaptic axonal connections. Two major anatomically and functionally distinct though …

Type I interferon (IFN) is a class of proinflammatory cytokines with a dual role on malignant
transformation, tumor progression, and response to therapy. On the one hand, robust, acute …

The past few years have provided important insights into the genetic architecture of systemic
autoimmunity through aggregation of findings from genome-wide association studies …

Although all multicellular organisms have germ line–encoded innate receptors to sense
pathogen-associated molecular patterns, vertebrates also evolved adaptive immunity based …

In genomic medicine, the concept of genetically transitional disease (GTD) refers to cases in
which gene mutation is necessary but not sufficient to cause disease. In this Perspective, we …

Autoimmune diseases are heterogeneous disorders believed to stem from the immune
system's inability to distinguish between auto-and foreign-antigens. B lymphocytes serve a …

Given the self-evident importance of cutaneous immunity in the maintenance of body-
surface homeostasis, disturbance of the steady-state skin is inextricably intertwined with …

(1) Background: The pathogenesis of systemic lupus erythematosus (SLE) involves
complicated and multifactorial interactions. Inducible nitric oxide synthase overactivation …

The therapeutic application of mesenchymal stem cells (MSCs) has good potential as a
treatment strategy for systemic lupus erythematosus (SLE), but traditional MSC therapy still …

As an autoimmune disease, systemic lupus erythematosus (SLE) can affect multiple organs
and systems. Whether SLE can increase the risk of coeliac disease (CeD) was not evaluated …