Actinomycetes continue to be important sources for the discovery of secondary metabolites
for applications in human medicine, animal health, and crop protection. With the maturation …

Covering: up to May 2012The β-lactam antibiotics and related β-lactamase inhibitors are
amongst the most important small molecules in clinical use. Most, but not all, β-lactams …

Covering up to end 2015 Microbial fermentation provides an attractive alternative to
chemical synthesis for the production of structurally complex natural products. In most cases …

The beta-lactam antibiotics have been serving mankind for over 70years. Despite this old
age, they continue to provide health to the world population by virtue of industrial production …

The β-lactamase inhibitor, clavulanic acid is frequently used in combination with β-lactam
antibiotics to treat a wide spectrum of infectious diseases. Clavulanic acid prevents drug …

Many microbial secondary metabolites are of high biotechnological value for medicine,
agriculture, and the food industry. Bacterial genome mining has revealed numerous novel …

Unlike the majority of actinomycete secondary metabolic pathways, the biosynthesis of
peptidoglycan glycosyltransferase inhibitor moenomycin in Streptomyces ghanaensis does …

Clavulanic acid (CA) is a potent β-lactamase inhibitor produced by Streptomyces
clavuligerus and has been successfully used in combination with β-lactam antibiotics (for …

Expression of non-native transcriptional activators may be a powerful general method to
activate secondary metabolites biosynthetic pathways. PAS-LuxR regulators, whose …

Clavulanic acid (CA) is an irreversible β-lactamase enzyme inhibitor with a weak
antibacterial activity produced by Streptomyces clavuligerus (S. clavuligerus). CA is typically …