Diffuse large B-cell lymphoma (DLBCL) is a clinically heterogeneous lymphoid malignancy
and the most common subtype of non-Hodgkin's lymphoma in adults, with one of the highest …

Metformin can suppress gluconeogenesis and reduce blood sugar by activating adenosine
monophosphate-activated protein kinase (AMPK) and inducing small heterodimer partner …

Adenosine monophosphate-activated protein kinase (AMPK) acts as a major sensor of
cellular energy status in cancers and is critically involved in cell sensitivity to anticancer …

Platelet activation is a key step in the pathogenesis of ischemic cardio-and cerebrovascular
diseases, which represent the leading causes of death and severe disability worldwide …

Abstract The phosphatidylinositiol 3-kinase (PI3K), AKT, mammalian target of rapamycin
(mTOR) signaling pathway (PI3K/AKT/mTOR) is frequently dysregulated in disorders of cell …

A complex interplay of intracellular signaling networks orchestrates normal cell growth and
survival, including translation, transcription, proliferation, and cell cycle progression …

BACKGROUND: SF1126 is a peptidic pro-drug inhibitor of pan-PI3K/mTORC. A first-in-
human study evaluated safety, dose limiting toxicities (DLT), maximum tolerated dose …

Signaling to the mechanistic target of rapamycin (mTOR) regulates diverse cellular
processes, including protein translation, cellular proliferation, metabolism, and autophagy …

An unresolved problem with clinical use of antiplatelet therapy is that a significant number of
individuals either still get thrombosis or run the risk of life-threatening bleeding. Antiplatelet …

The mammalian target of rapamycin (mTOR) plays crucial roles in proliferative and
antiapoptotic signaling in lymphoid malignancies. Rapamycin analogs, which are allosteric …