Acetylcholinesterase inhibitors (nerve agents) as weapons of mass destruction: History, mechanisms of action, and medical countermeasures
V Aroniadou-Anderjaska, JP Apland, TH Figueiredo… - …, 2020 - Elsevier
Nerve agents are organophosphorus acetylcholinesterase inhibitors. Acute exposure to
nerve agents can cause rapid death. In this review, we summarize the history of nerve agent …
nerve agents can cause rapid death. In this review, we summarize the history of nerve agent …
Progress report on new antiepileptic drugs: A summary of the Fifteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XV). I. Drugs in preclinical …
M Bialer, SI Johannessen, MJ Koepp, RH Levy… - …, 2020 - Wiley Online Library
Abstract Since 1992, the Eilat Conferences have provided a forum for all stakeholders in the
epilepsy community to appraise the latest data on new antiepileptic drugs and emergency …
epilepsy community to appraise the latest data on new antiepileptic drugs and emergency …
Catalyst-controlled doubly enantioconvergent coupling of racemic alkyl nucleophiles and electrophiles
H Huo, BJ Gorsline, GC Fu - Science, 2020 - science.org
Stereochemical control in the construction of carbon-carbon bonds between an alkyl
electrophile and an alkyl nucleophile is a persistent challenge in organic synthesis …
electrophile and an alkyl nucleophile is a persistent challenge in organic synthesis …
Current and future pharmacotherapy options for drug-resistant epilepsy
S Elkommos, M Mula - Expert opinion on pharmacotherapy, 2022 - Taylor & Francis
Introduction Epilepsy is a common neurological condition, affecting over 70 million
individuals worldwide. Areas covered The present paper reviews current and future (under …
individuals worldwide. Areas covered The present paper reviews current and future (under …
[HTML][HTML] Novel drugs and early polypharmacotherapy in status epilepticus
M Amengual-Gual, IS Fernández, MS Wainwright - Seizure, 2019 - Elsevier
Purpose Rescue medications for status epilepticus (SE) have a relatively high rate of failure.
The purpose of this review is to summarize the evidence for the efficacy of novel drugs and …
The purpose of this review is to summarize the evidence for the efficacy of novel drugs and …
Ketamine as adjunct to midazolam treatment following soman-induced status epilepticus reduces seizure severity, epileptogenesis, and brain pathology in plasma …
BM Marrero-Rosado, M de Araujo Furtado… - Epilepsy & Behavior, 2020 - Elsevier
Delayed treatment of cholinergic seizure results in benzodiazepine-refractory status
epilepticus (SE) that is thought, at least in part, to result from maladaptive trafficking of N …
epilepticus (SE) that is thought, at least in part, to result from maladaptive trafficking of N …
α-Linolenic acid, a nutraceutical with pleiotropic properties that targets endogenous neuroprotective pathways to protect against organophosphate nerve agent …
T Piermartiri, H Pan, TH Figueiredo, AM Marini - Molecules, 2015 - mdpi.com
α-Linolenic acid (ALA) is a nutraceutical found in vegetable products such as flax and
walnuts. The pleiotropic properties of ALA target endogenous neuroprotective and …
walnuts. The pleiotropic properties of ALA target endogenous neuroprotective and …
Refractory and super-refractory status epilepticus in nerve agent-poisoned rats following application of standard clinical treatment guidelines
JE Morgan, SC Wilson, BJ Travis, KH Bagri… - Frontiers in …, 2021 - frontiersin.org
Nerve agents (NAs) induce a severe cholinergic crisis that can lead to status epilepticus
(SE). Current guidelines for treatment of NA-induced SE only include prehospital …
(SE). Current guidelines for treatment of NA-induced SE only include prehospital …
Comparative efficacy of valnoctamide and sec‐butylpropylacetamide (SPD) in terminating nerve agent–induced seizures in pediatric rats
Objectives Children and adults are likely to be among the casualties in a civilian nerve agent
exposure. This study evaluated the efficacy of valnoctamide (racemic‐VCD), sec …
exposure. This study evaluated the efficacy of valnoctamide (racemic‐VCD), sec …
Comparative teratogenicity analysis of valnoctamide, risperidone, and olanzapine in mice
BJ Wlodarczyk, K Ogle, LY Lin, M Bialer… - Bipolar …, 2015 - Wiley Online Library
Objectives Based on the recent findings from animal studies, it has been proposed that the
therapeutic use of valnoctamide, an anxiolytic drug developed in the early 1960s, be …
therapeutic use of valnoctamide, an anxiolytic drug developed in the early 1960s, be …