Plastics are widely used in the global economy, and each year, at least 350 to 400 million
tons are being produced. Due to poor recycling and low circular use, millions of tons …

Marine dissolved organic matter (DOM) contains more carbon than the combined stocks of
Earth's biota. Organisms in the ocean continuously release a myriad of molecules that …

Sequence-based prediction of drug–target interactions has the potential to accelerate drug
discovery by complementing experimental screens. Such computational prediction needs to …

Enzymes are versatile catalysts and their synthetic potential has been recognized for a long
time. In order to exploit their full potential, enzymes often need to be re-engineered or …

Global economies depend on the use of fossil‐fuel‐based polymers with 360–400 million
metric tons of synthetic polymers being produced per year. Unfortunately, an estimated 60 …

Oligonucleotides are almost exclusively synthesized using the nucleoside phosphoramidite
method, even though it is limited to the direct synthesis of∼ 200 mers and produces …

Biocatalysis is a promising approach to sustainably synthesize pharmaceuticals, complex
natural products, and commodity chemicals at scale. However, the adoption of biocatalysis …

Polyethylene terephthalate (PET) is a commodity polymer known to globally contaminate
marine and terrestrial environments. Today, around 80 bacterial and fungal PET-active …

Pepsin is a protease used in many different applications, and in many instances, it is utilized
in an immobilized form to prevent contamination of the reaction product. This enzyme has …

Finding new mechanistic solutions for biocatalytic challenges is key in the evolutionary
adaptation of enzymes, as well as in devising new catalysts. The recent release of man …