Klebsiella pneumoniae is a common cause of antimicrobial-resistant opportunistic infections
in hospitalized patients. The species is naturally resistant to penicillins, and members of the …

Klebsiella pneumoniae is a Gram-negative pathogen that has a large accessory genome of
plasmids and chromosomal gene loci. This accessory genome divides K. pneumoniae …

Gram-negative bacteremia is a devastating public health threat, with high mortality in
vulnerable populations and significant costs to the global economy. Concerningly, rates of …

Hypervirulence and carbapenem resistance have emerged as two distinct evolutionary
directions for Klebsiella pneumoniae, which pose a great threat in clinical settings. Multiple …

Klebsiella pneumoniae is now recognized as an urgent threat to human health because of
the emergence of multidrug-resistant strains associated with hospital outbreaks and …

Klebsiella pneumoniae is an important opportunistic pathogen that commonly causes
nosocomial infections and contributes to substantial morbidity and mortality. We sought to …

Rational: Intracellular bacterial survival is a major factor causing chronic or recurrent
infection, leading to the failure of both host defense and/or antibiotic treatment. However, the …

Iron is an essential nutrient for life. During infection, a fierce battle of iron acquisition occurs
between the host and bacterial pathogens. Bacteria acquire iron by secreting siderophores …

Mobile genetic elements (MGEs) that frequently transfer within and between bacterial
species play a critical role in bacterial evolution, and often carry key accessory genes that …

Antibiotic resistance, prompted by the overuse of antimicrobial agents, may arise from a
variety of mechanisms, particularly horizontal gene transfer of virulence and antibiotic …