Abstract The cytokine interleukin-12 (IL-12) was thought to have a central role in T cell–
mediated responses in inflammation for more than a decade after it was first identified …

Cytokines related to tumor necrosis factor (TNF) provide a communication network essential
for coordinating multiple cell types into an effective host defense system against pathogens …

Understanding the functional consequences of genetic variation, and how it affects complex
human disease and quantitative traits, remains a critical challenge for biomedicine. We …

Patients with a diverse spectrum of rare genetic disorders can present with inflammatory
bowel disease (monogenic IBD). Patients with these disorders often develop symptoms …

Genome-wide association studies and candidate gene studies in ulcerative colitis have
identified 18 susceptibility loci. We conducted a meta-analysis of six ulcerative colitis …

Background Temporal trends in the incidence of pediatric-onset inflammatory bowel disease
(IBD) are controversial and a wide range of estimates have been reported worldwide. We …

Interleukin (IL)-22–producing group 3 innate lymphoid cells (ILC3) promote mucosal healing
and maintain barrier integrity, but how microbial signals are integrated to regulate mucosal …

Complex disease genetics has been revolutionised in recent years by the advent of genome-
wide association (GWA) studies. The chronic inflammatory bowel diseases (IBDs), Crohn's …

BACKGROUND & AIMS: Homozygous loss of function mutations in interleukin-10 (IL10) and
interleukin-10 receptors (IL10R) cause severe infantile (very early onset) inflammatory …

Abstract Interleukin 10 (IL10) is a key anti-inflammatory cytokine that can inhibit
proinflammatory responses of both innate and adaptive immune cells. An association …