Autophagy and mitophagy act in cancer as bimodal processes, whose differential functions
strictly depend on cancer ontogenesis, progression, and type. For instance, they can act to …

The potential roles of breast cancer stem cells (BCSCs) in tumor initiation and recurrence
have been recognized for many decades. Due to their strong capacity for self-renewal and …

The forkhead box O (FOXO) transcription factors are considered as tumor suppressors that
limit cell proliferation and induce apoptosis. FOXO gene alterations have been described in …

Background Patients with gastric cancer commonly have a poor prognosis, owing to its
invasiveness and distant metastasis. Recent studies have confirmed the pivotal role of long …

Breast cancer stem cells (BCSCs) are tumor initiating cells that can self-renew and are
highly tumorigenic and chemoresistant. Therefore, the identification of factors critical for …

FOXO transcription factors are negatively regulated by the PI3K-PKB/AKT signaling pathway
and have been mainly considered to be tumor suppressors due to their inhibitory effect on …

Purpose Studies show that high expression of non-SMC condensin I complex subunit G
(NCAPG) is associated with many tumors. In this study, we explore the mechanism by which …

Despite an increase in the incidence of breast cancer worldwide, overall prognosis has
been consistently improving owing to the development of multiple targeted therapies and …

Cell identity is largely determined by its transcriptional profile. In tumour, deregulation of
transcription factor expression and/or activity enables cancer cell to acquire a stem-like state …

Circular RNAs (circRNAs) are a type of noncoding RNAs with a closed loop structure. With
the development of high-throughput sequencing, massive circRNAs have been discovered …