The brain harbors a unique ability to, figuratively speaking, shift its gears. During
wakefulness, the brain is geared fully toward processing information and behaving, while …

Soft connective tissues at steady state are dynamic; resident cells continually read
environmental cues and respond to them to promote homeostasis, including maintenance of …

Arterial aging engages a plethora of key signalling pathways that act in concert to induce
vascular smooth muscle cell (VSMC) phenotypic changes leading to vascular degeneration …

Abstract Purpose of Review Organ fibrosis is a lethal component of scleroderma. The
hallmark of scleroderma fibrosis is extensive extracellular matrix (ECM) deposition by …

Just as the epigenome, the proteome and the electrophysiological properties of a cell
influence its function, so too do its intrinsic mechanical properties and its extrinsic …

Integrin-dependent interactions between T cells and antigen-presenting cells are vital for
proper T cell activation, effector function, and memory. Regulation of integrin function occurs …

Calreticulin is a highly conserved endoplasmic reticulum chaperone protein which
participates in various cellular processes. It was first identified as a Ca2+‐binding protein in …

A cell constantly adapts to its environment. Cell decisions to survive, to proliferate or to
migrate are dictated not only by soluble growth factors, but also through the direct interaction …

Calmodulin (CaM) is the principal Ca2+ sensor protein in all eukaryotic cells, that upon
binding to target proteins transduces signals encoded by global or subcellular-specific …

The tumor microenvironment (TME) is a complex macromolecular network filled with a series
of stromal cells. It plays an important role in tumorigenesis, development, immune escape …