Religious orders study and rush memory and aging project
DA Bennett, AS Buchman, PA Boyle… - Journal of …, 2018 - content.iospress.com
Background: The Religious Orders Study and Rush Memory and Aging Project are both
ongoing longitudinal clinical-pathologic cohort studies of aging and Alzheimer's disease …
ongoing longitudinal clinical-pathologic cohort studies of aging and Alzheimer's disease …
The chronic and evolving neurological consequences of traumatic brain injury
Traumatic brain injury (TBI) can have lifelong and dynamic effects on health and wellbeing.
Research on the long-term consequences emphasises that, for many patients, TBI should be …
Research on the long-term consequences emphasises that, for many patients, TBI should be …
Large-scale deep multi-layer analysis of Alzheimer's disease brain reveals strong proteomic disease-related changes not observed at the RNA level
The biological processes that are disrupted in the Alzheimer's disease (AD) brain remain
incompletely understood. In this study, we analyzed the proteomes of more than 1,000 brain …
incompletely understood. In this study, we analyzed the proteomes of more than 1,000 brain …
Single cell RNA sequencing of human microglia uncovers a subset associated with Alzheimer's disease
The extent of microglial heterogeneity in humans remains a central yet poorly explored
question in light of the development of therapies targeting this cell type. Here, we investigate …
question in light of the development of therapies targeting this cell type. Here, we investigate …
Large-scale proteomic analysis of Alzheimer's disease brain and cerebrospinal fluid reveals early changes in energy metabolism associated with microglia and …
Our understanding of Alzheimer's disease (AD) pathophysiology remains incomplete. Here
we used quantitative mass spectrometry and coexpression network analysis to conduct the …
we used quantitative mass spectrometry and coexpression network analysis to conduct the …
In vivo and neuropathology data support locus coeruleus integrity as indicator of Alzheimer's disease pathology and cognitive decline
Several autopsy studies recognize the locus coeruleus (LC) as the initial site of
hyperphosphorylated TAU aggregation, and as the number of LC neurons harboring TAU …
hyperphosphorylated TAU aggregation, and as the number of LC neurons harboring TAU …
The Parkinson's disease protein alpha-synuclein is a modulator of processing bodies and mRNA stability
Alpha-synuclein (αS) is a conformationally plastic protein that reversibly binds to cellular
membranes. It aggregates and is genetically linked to Parkinson's disease (PD). Here, we …
membranes. It aggregates and is genetically linked to Parkinson's disease (PD). Here, we …
[HTML][HTML] An epigenetic biomarker of aging for lifespan and healthspan
Identifying reliable biomarkers of aging is a major goal in geroscience. While the first
generation of epigenetic biomarkers of aging were developed using chronological age as a …
generation of epigenetic biomarkers of aging were developed using chronological age as a …
[HTML][HTML] Multiscale analysis of independent Alzheimer's cohorts finds disruption of molecular, genetic, and clinical networks by human herpesvirus
Investigators have long suspected that pathogenic microbes might contribute to the onset
and progression of Alzheimer's disease (AD) although definitive evidence has not been …
and progression of Alzheimer's disease (AD) although definitive evidence has not been …
Explainable AI for clinical and remote health applications: a survey on tabular and time series data
F Di Martino, F Delmastro - Artificial Intelligence Review, 2023 - Springer
Abstract Nowadays Artificial Intelligence (AI) has become a fundamental component of
healthcare applications, both clinical and remote, but the best performing AI systems are …
healthcare applications, both clinical and remote, but the best performing AI systems are …