The vitamin D receptor (VDR) belongs to the nuclear receptor superfamily of transcription
factors. The VDR is expressed in diverse brain regions and has been implicated in the …

Neurological disorders are the major cause of disability, leading to a decrease in quality of
life by impairing cognitive, sensorimotor, and motor functioning. Several factors have been …

Calcium is a ubiquitous second messenger that is indispensable in regulating
neurotransmission and memory formation. A precise intracellular calcium level is achieved …

Aims Vitamin D is a well-known endocrine regulator of calcium/phosphate homeostasis and
has been reported as having a wide range of activities that are potentially beneficial for …

The present study aimed to investigate the effects of vitamin D3 (Vit D) administration on
memory function, hippocampal level of amyloid-beta (Aβ), brain-derived neurotrophic factor …

Alzheimer's disease (AD) is the most common cause of dementia. In recent years, several
studies have robustly shown that neuroinflammation plays a crucial role in the …

Finding an effective anti-Alzheimer agent is quite challenging due to its multifactorial nature.
As such, multitarget directed ligands (MTDLs) could be a promising paradigm for finding …

Throughout life, organisms are exposed to various exogenous and endogenous factors that
cause DNA damages and somatic mutations provoking genomic instability. At a young age …

Evidence is increasing that vitamin D and CYP11A1-derived vitamin D, tachysterol, and
lumisterol metabolites play a significant antioxidant role beyond its classical functions in …

Vitamin D3 (VD) is a secosteroid hormone and shows a pleiotropic effect in brain-related
disorders where it regulates redox imbalance, inflammation, apoptosis, energy production …