Heterogeneous anomalous transport in cellular and molecular biology

TA Waigh, N Korabel - Reports on Progress in Physics, 2023 - iopscience.iop.org
It is well established that a wide variety of phenomena in cellular and molecular biology
involve anomalous transport eg the statistics for the motility of cells and molecules are …

[HTML][HTML] The rich inner life of the cell nucleus: dynamic organization, active flows, and emergent rheology

A Zidovska - Biophysical Reviews, 2020 - Springer
The cell nucleus stores the genetic material essential for life, and provides the environment
for transcription, maintenance, and replication of the genome. Moreover, the nucleoplasm is …

[HTML][HTML] The physics of active polymers and filaments

RG Winkler, G Gompper - The journal of chemical physics, 2020 - pubs.aip.org
Active matter agents consume internal energy or extract energy from the environment for
locomotion and force generation. Already, rather generic models, such as ensembles of …

Polymer folding through active processes recreates features of genome organization

A Goychuk, D Kannan… - Proceedings of the …, 2023 - National Acad Sciences
From proteins to chromosomes, polymers fold into specific conformations that control their
biological function. Polymer folding has long been studied with equilibrium thermodynamics …

Activity-induced collapse and arrest of active polymer rings

E Locatelli, V Bianco, P Malgaretti - Physical Review Letters, 2021 - APS
We investigate, using numerical simulations, the conformations of isolated active ring
polymers. We find that their behavior depends crucially on their size: Short rings (N≲ 100) …

Self-Organized States from Solutions of Active Ring Polymers in Bulk and under Confinement

JP Miranda, E Locatelli, C Valeriani - Journal of Chemical Theory …, 2023 - ACS Publications
In the present work, we study, by means of numerical simulations, the structural and
dynamical behavior of a suspension of active ring polymers in bulk and under lateral …

Euchromatin activity enhances segregation and compaction of heterochromatin in the cell nucleus

A Mahajan, W Yan, A Zidovska, D Saintillan… - Physical Review X, 2022 - APS
The large-scale organization of the genome inside the cell nucleus is critical for the cell's
function. Chromatin—the functional form of DNA in cells—serves as a template for active …

Tangentially driven active polar linear polymers—An analytical study

CA Philipps, G Gompper, RG Winkler - The Journal of Chemical …, 2022 - pubs.aip.org
The conformational and dynamical properties of isolated flexible active polar linear polymers
(APLPs) are studied analytically. The APLPs are modeled as Gaussian bead-spring linear …

The scales, mechanisms, and dynamics of the genome architecture

L Lizana, YB Schwartz - Science Advances, 2024 - science.org
Even when split into several chromosomes, DNA molecules that make up our genome are
too long to fit into the cell nuclei unless massively folded. Such folding must accommodate …

Harnessing the power of chemically active sheets in solution

RK Manna, A Laskar, OE Shklyaev… - Nature Reviews …, 2022 - nature.com
In living organisms, diffusing chemicals react with soft tissue to actuate a range of
mechanical actions, such as periodic pulsations or net motion. Inspired by this biological …