New insights into the molecular and cellular functions of poly (ADP-ribose) and PARPs
Abstract Poly (ADP-ribose) polymerases (PARPs) are enzymes that transfer ADP-ribose
groups to target proteins and thereby affect various nuclear and cytoplasmic processes. The …
groups to target proteins and thereby affect various nuclear and cytoplasmic processes. The …
The P2X7 receptor channel: recent developments and the use of P2X7 antagonists in models of disease
The P2X7 receptor is a trimeric ATP-gated cation channel found predominantly, but not
exclusively, on immune cells. P2X7 activation results in a number of downstream events …
exclusively, on immune cells. P2X7 activation results in a number of downstream events …
The role of poly ADP-ribosylation in the first wave of DNA damage response
Poly ADP-ribose polymerases (PARPs) catalyze massive protein poly ADP-ribosylation
(PARylation) within seconds after the induction of DNA single-or double-strand breaks …
(PARylation) within seconds after the induction of DNA single-or double-strand breaks …
PARP-1 involvement in neurodegeneration: a focus on Alzheimer's and Parkinson's diseases
DNA damage is the prime activator of the enzyme poly (ADP-ribose) polymerase1 (PARP-1)
whose overactivation has been proven to be associated with the pathogenesis of numerous …
whose overactivation has been proven to be associated with the pathogenesis of numerous …
Nuclear poly (ADP-ribose) activity is a therapeutic target in amyotrophic lateral sclerosis
L McGurk, J Mojsilovic-Petrovic, VM Van Deerlin… - Acta neuropathologica …, 2018 - Springer
Amyotrophic lateral sclerosis (ALS) is a devastating and fatal motor neuron disease.
Diagnosis typically occurs in the fifth decade of life and the disease progresses rapidly …
Diagnosis typically occurs in the fifth decade of life and the disease progresses rapidly …
Biological processes and signal transduction pathways regulated by the protein methyltransferase SETD7 and their significance in cancer
IAA Batista, LA Helguero - Signal transduction and targeted therapy, 2018 - nature.com
Protein methyltransferases have been shown to methylate histone and non-histone proteins,
leading to regulation of several biological processes that control cell homeostasis. Over the …
leading to regulation of several biological processes that control cell homeostasis. Over the …
Bacteroidetes Neurotoxins and Inflammatory Neurodegeneration
Y Zhao, WJ Lukiw - Molecular Neurobiology, 2018 - Springer
The gram-negative facultative anaerobe Bacteroides fragilis (B. fragilis) constitutes an
appreciable proportion of the human gastrointestinal (GI)-tract microbiome. As is typical of …
appreciable proportion of the human gastrointestinal (GI)-tract microbiome. As is typical of …
Nuclear glutathione
JL García-Giménez, J Markovic, F Dasí… - … et Biophysica Acta (BBA …, 2013 - Elsevier
Glutathione (GSH) is a linchpin of cellular defences in plants and animals with
physiologically-important roles in the protection of cells from biotic and abiotic stresses …
physiologically-important roles in the protection of cells from biotic and abiotic stresses …
PARP2 is the predominant poly (ADP-ribose) polymerase in Arabidopsis DNA damage and immune responses
Poly (ADP-ribose) polymerases (PARPs) catalyze the transfer of multiple poly (ADP-ribose)
units onto target proteins. Poly (ADP-ribosyl) ation plays a crucial role in a variety of cellular …
units onto target proteins. Poly (ADP-ribosyl) ation plays a crucial role in a variety of cellular …
PARP-1 regulates inflammasome activity by poly-ADP-ribosylation of NLRP3 and interaction with TXNIP in primary macrophages
LY Chiu, DY Huang, WW Lin - Cellular and Molecular Life Sciences, 2022 - Springer
Abstract Poly (ADP-ribose) polymerase-1 (PARP-1) plays an essential role in DNA repair by
catalyzing the polymerization of ADP-ribose unit to target proteins. Several studies have …
catalyzing the polymerization of ADP-ribose unit to target proteins. Several studies have …