Preservation of gonadal function is an important priority for the long-term health of cancer
survivors of both sexes and all ages at treatment. Loss of opportunity for fertility is a prime …

Biochemical measurements of bone turnover are helpful in the study of the pathophysiology
of skeletal metabolism and growth. However, interpretation of their results is difficult because …

Pancytopenia is a major cause of morbidity in acute myeloid leukemia (AML), yet its cause is
unclear. Normal osteoblastic cells have been shown to support hematopoiesis. To define the …

The demography of differentiated thyroid cancers (DTCs) has changed considerably since
the 1990s, when the vast majority of these tumors were clinically evident at the time of …

Objective: To evaluate fracture rate and bone mineral density (BMD) and body composition
in children with acute lymphoblastic leukemia (ALL) treated with dexamethasone-based …

Arch Dis Child: first published as 10.1136/adc. 87.2. 93 on 1 August 2002. Downloaded from
confounding factors including the plethora of drugs, delivery systems, compliance, and …

The bone marrow niche is thought to act as a permissive microenvironment required for
emergence or progression of hematologic cancers. We hypothesized that osteoblasts …

In the past decades, new cancer treatment approaches for children and adolescents have
led to a decrease in recurrence rates and an increase in long-term survival. Recent studies …

Endocrine complications of therapy for acute lymphoblastic leukemia (ALL) are common and
are potentially debilitating both during and after therapy. Growth velocity slows during …

Although substantial increases in survival rates among children diagnosed with cancer have
been observed in recent decades, survivors are at risk of developing therapy-related chronic …