Monoclonal antibodies (mAbs) are appealing as potential therapeutics and prophylactics for
viral infections owing to characteristics such as their high specificity and their ability to …

Herpesviruses are ubiquitous, double-stranded DNA, enveloped viruses that establish
lifelong infections and cause a range of diseases. Entry into host cells requires binding of …

CMV is an ancient herpesvirus that has co-evolved with its host over millions of years. The
236 kbp genome encodes at least 165 genes, four non-coding RNAs and 14 miRNAs. Of the …

Characterizing cell surface receptors mediating viral infection is critical for understanding
viral tropism and developing antiviral therapies. Nevertheless, due to challenges associated …

The past few years have brought substantial progress toward understanding how human
cytomegalovirus (HCMV) enters the remarkably wide spectrum of cell types and tissues that …

Herpesvirus gH/gL envelope glycoprotein complexes are key players in virus entry as
ligands for host cell receptors and by promoting fusion of viral envelopes with cellular …

Human cytomegalovirus (HCMV) is a beta herpesvirus that establishes a life-long
persistence in the host, like all herpesviruses, by way of a latent infection. During latency …

Although congenital infection by human cytomegalovirus (HCMV) is well recognized as a
leading cause of neurodevelopmental defects, HCMV neuropathogenesis remains poorly …

Human cytomegalovirus (hCMV) is one of the most common causes of congenital infection
in the post-rubella era, representing a major public health concern. Although most cases are …

In the 1970s–1980s, a striking increase in the number of disseminated human
cytomegalovirus (HCMV) infections occurred in immunosuppressed patient populations …