A remarkable epigenetic remodelling process occurs shortly after fertilization, which restores
totipotency to the zygote. This involves global DNA demethylation, chromatin remodelling …

Pluripotent stem cells (PSCs) are characterized by their unique capacity for both unlimited
self-renewal and their potential to differentiate to all cell lineages contained within the three …

Zygotic genome activation (ZGA) is a critical postfertilization step that promotes totipotency
and allows different cell fates to emerge in the developing embryo. MERVL (murine …

The solid tumour microenvironment includes nerve fibres that arise from the peripheral
nervous system,. Recent work indicates that newly formed adrenergic nerve fibres promote …

Totipotent cells have more robust developmental potency than any other cell types, giving
rise to both embryonic and extraembryonic tissues. Stable totipotent cell cultures and …

Since establishment of the first embryonic stem cells (ESCs), in vitro culture of totipotent cells
functionally and molecularly comparable with in vivo blastomeres with embryonic and …

To better understand transcriptional regulation during human oogenesis and
preimplantation development, we defined stage-specific transcription, which highlighted the …

Totipotency is the ability of a single cell to give rise to all of the differentiated cell types that
build the conceptus, yet how to capture this property in vitro remains incompletely …

Abstract H3K9me3-dependent heterochromatin is a major barrier of cell fate changes that
must be reprogrammed after fertilization. However, the molecular details of these events are …

In mammalian embryos, proper zygotic genome activation (ZGA) underlies totipotent
development. Double homeobox (DUX)-family factors participate in ZGA, and mouse Dux is …