What coronavirus 3C‐like protease tells us: from structure, substrate selectivity, to inhibitor design
M Xiong, H Su, W Zhao, H Xie… - Medicinal research …, 2021 - Wiley Online Library
The emergence of a variety of coronaviruses (CoVs) in the last decades has posed huge
threats to human health. Especially, the ongoing pandemic of coronavirus disease 2019 …
threats to human health. Especially, the ongoing pandemic of coronavirus disease 2019 …
Recent drug development and medicinal chemistry approaches for the treatment of SARS‐CoV‐2 infection and COVID‐19
Abstract COVID‐19, caused by SARS‐CoV‐2 infection, continues to be a major public
health crisis around the globe. Development of vaccines and the first cluster of antiviral …
health crisis around the globe. Development of vaccines and the first cluster of antiviral …
Covalent narlaprevir-and boceprevir-derived hybrid inhibitors of SARS-CoV-2 main protease
DW Kneller, H Li, G Phillips, KL Weiss, Q Zhang… - Nature …, 2022 - nature.com
Emerging SARS-CoV-2 variants continue to threaten the effectiveness of COVID-19
vaccines, and small-molecule antivirals can provide an important therapeutic treatment …
vaccines, and small-molecule antivirals can provide an important therapeutic treatment …
Peptidomimetic α-acyloxymethylketone warheads with six-membered lactam P1 glutamine mimic: SARS-CoV-2 3CL protease inhibition, coronavirus antiviral activity …
B Bai, A Belovodskiy, M Hena… - Journal of Medicinal …, 2021 - ACS Publications
Recurring coronavirus outbreaks, such as the current COVID-19 pandemic, establish a
necessity to develop direct-acting antivirals that can be readily administered and are active …
necessity to develop direct-acting antivirals that can be readily administered and are active …
Perspectives on SARS-CoV-2 main protease inhibitors
The main protease (Mpro) plays a crucial role in severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) replication and is highly conserved, rendering it one of the …
coronavirus 2 (SARS-CoV-2) replication and is highly conserved, rendering it one of the …
Open quantum system dynamics and the mean force Gibbs state
The dynamical convergence of a system to the thermal distribution, or Gibbs state, is a
standard assumption across all of the physical sciences. The Gibbs state is determined just …
standard assumption across all of the physical sciences. The Gibbs state is determined just …
Similarities and dissimilarities of COVID-19 and other coronavirus diseases
TS Fung, DX Liu - Annual review of microbiology, 2021 - annualreviews.org
In less than two decades, three deadly zoonotic coronaviruses, severe acute respiratory
syndrome coronavirus (SARS-CoV), Middle East respiratory syndrome coronavirus (MERS …
syndrome coronavirus (SARS-CoV), Middle East respiratory syndrome coronavirus (MERS …
Benchmarking the ability of common docking programs to correctly reproduce and score binding modes in SARS-CoV-2 protease Mpro
The coronavirus SARS-CoV-2 main protease, Mpro, is conserved among coronaviruses with
no human homolog and has therefore attracted significant attention as an enzyme drug …
no human homolog and has therefore attracted significant attention as an enzyme drug …
Ultrafast one-minute electronic detection of SARS-CoV-2 infection by 3CLpro enzymatic activity in untreated saliva samples
E Borberg, E Granot, F Patolsky - Nature Communications, 2022 - nature.com
Since its onset in December 2019, severe acute respiratory syndrome coronavirus 2, SARS-
CoV-2, has caused over 6.5 million deaths worldwide as of October 2022. Attempts to curb …
CoV-2, has caused over 6.5 million deaths worldwide as of October 2022. Attempts to curb …
Molecular Docking Studies on the Anti-viral Effects of Compounds From Kabasura Kudineer on SARS-CoV-2 3CLpro
The COVID-19 has now been declared a global pandemic by the World Health
Organization. No approved drug is currently available; therefore, an urgent need has been …
Organization. No approved drug is currently available; therefore, an urgent need has been …