OBJECTIVE: The aim of the study was to consider statistical and methodological issues
affecting the results of meta-analysis of genetic association studies for pertinent gene …

Age-related cerebral small-vessel disease (CSVD) is a major cause of stroke and dementia.
Despite a widespread acceptance of small-vessel arteriopathy, lacunar infarction, diffuse …

Vascular cognitive impairment and dementia (VCID) is the second most common form of
dementia after Alzheimer's disease (AD). Currently, the mechanistic insights into the …

Background Numerous individually underpowered association studies have been
conducted on endothelial nitric oxide synthase (eNOS) genetic variants across different …

Meta‐analysis is the quantitative synthesis of information from several studies. It is
applicable to a variety of study designs in genetics, from family‐based linkage studies and …

Ischemic vascular remodeling occurs in response to stenosis or arterial occlusion leading to
a change in blood flow and tissue perfusion. Altered blood flow elicits a cascade of …

Background Many studies have investigated the association between the angiotensin-
converting enzyme (ACE) gene insertion (I)/deletion (D) polymorphic variant and coronary …

To date, linkage and association studies have not been convincing. Genome-wide
association studies may prove to be an effective approach to the problems posed by …

Essential hypertension is a common disorder that leads to significant morbidity and mortality;
however, the underlying mechanisms have remained elusive. Recent animal model studies …

The angiotensin II type 1 receptor (AGTR1) plays an integral role in blood pressure control,
and is implicated in the pathogenesis of hypertension. Polymorphisms within this gene have …