PURPOSE Allogeneic hematopoietic cell transplantation (HCT) in patients with
myelodysplastic syndrome (MDS) improves overall survival (OS). We evaluated the impact …

Recognition of aberrant gene isoforms due to DNA events can impact risk stratification and
molecular classification of hematolymphoid tumors. In myelodysplastic syndromes, KMT2A …

The ubiquitin‑proteasome system is a major degradation pathway for> 80% of proteins in
vivo. Deubiquitylases, which remove ubiquitinated tags to stabilize substrate proteins, are …

Somatic copy number variations (CNVs), including abnormal chromosome numbers and
structural changes leading to gain or loss of genetic material, play a crucial role in initiation …

Dear Editors, Acute myeloid leukemia (AML) can be classified into multiple genetic subtypes
based on recurrent pathogenic structural variants (SVs), copy number abnormalities (CNAs) …

Simple Summary Genetic rearrangements of the KMT2A gene are associated with
diagnostic and prognostic outcomes in the context of myeloid neoplasms. While …

Background: For prediction on leukemic transformation of MDS patients, emerging model
based on transcriptomic datasets, exhibited superior predictive power to traditional …

Recognition of aberrant gene isoforms indicative of underlying DNA events can impact
molecular classification and risk stratification of B lymphoblastic leukemia (B-ALL). Aberrant …

Myeloid malignancies are influenced by various genetic and epigenetic influences,
manifested by excessive proliferation, abnormal self-renewal, and/or differentiation defects …

Our current understanding of epigenetic regulation is deeply rooted in the founding
contributions of Dr. C. David Allis. In 2002, Allis and colleagues first characterized the lysine …