Label-free microfluidic cell sorting and detection for rapid blood analysis

N Lu, HM Tay, C Petchakup, L He, L Gong, KK Maw… - Lab on a Chip, 2023 - pubs.rsc.org
Blood tests are considered as standard clinical procedures to screen for markers of diseases
and health conditions. However, the complex cellular background (> 99.9% RBCs) and …

Future of digital assays to resolve clinical heterogeneity of single extracellular vesicles

RTT Morales, J Ko - ACS nano, 2022 - ACS Publications
Extracellular vesicles (EVs) are complex lipid membrane vehicles with variable expressions
of molecular cargo, composed of diverse subpopulations that participate in the intercellular …

Innovations in spray drying process for food and pharma industries

K Samborska, S Poozesh, A Barańska… - Journal of Food …, 2022 - Elsevier
The article presents a literature review on modifications and the latest achievements in the
field of spray drying (SD). Although the history of this method of drying dates back to more …

High-throughput screening by droplet microfluidics: Perspective into key challenges and future prospects

EM Payne, DA Holland-Moritz, S Sun, RT Kennedy - Lab on a Chip, 2020 - pubs.rsc.org
In two decades of development, impressive strides have been made for automating basic
laboratory operations in droplet-based microfluidics, allowing the emergence of a new form …

Basic principles and recent advances in magnetic cell separation

M Frenea-Robin, J Marchalot - Magnetochemistry, 2022 - mdpi.com
Magnetic cell separation has become a key methodology for the isolation of target cell
populations from biological suspensions, covering a wide spectrum of applications from …

Isolation of tumour-reactive lymphocytes from peripheral blood via microfluidic immunomagnetic cell sorting

Z Wang, S Ahmed, M Labib, H Wang, L Wu… - Nature Biomedical …, 2023 - nature.com
The clinical use of tumour-infiltrating lymphocytes for the treatment of solid tumours is
hindered by the need to obtain large and fresh tumour fractions, which is often not feasible in …

Deterministic sorting of submicrometer particles and extracellular vesicles using a combined electric and acoustic field

M Tayebi, D Yang, DJ Collins, Y Ai - Nano Letters, 2021 - ACS Publications
Sorting of extracellular vesicles has important applications in early stage diagnostics.
Current exosome isolation techniques, however, suffer from being costly, having long …

Efficient recovery of potent tumour-infiltrating lymphocytes through quantitative immunomagnetic cell sorting

Z Wang, S Ahmed, M Labib, H Wang, X Hu… - Nature Biomedical …, 2022 - nature.com
Adoptive cell therapies require the recovery and expansion of highly potent tumour-
infiltrating lymphocytes (TILs). However, TILs in tumours are rare and difficult to isolate …

Bipolar electrode-based sheath-less focusing and continuous acoustic sorting of particles and cells in an integrated microfluidic device

Y Wu, X Ma, K Li, Y Yue, Z Zhang, Y Meng… - Analytical …, 2024 - ACS Publications
Sheath-less focusing and sorting of cells or particles is an important preprocessing step in a
variety of biochemical applications. Most of the previous sorting methods depend on the use …

High-throughput separation, trapping, and manipulation of single cells and particles by combined dielectrophoresis at a bipolar electrode array

Y Wu, Y Ren, Y Tao, L Hou, H Jiang - Analytical chemistry, 2018 - ACS Publications
Microfluidic systems have been developed widely in scaled-down processes of laboratory
techniques, but they are usually limited in achieving stand-alone functionalities. It is highly …