Chronic cerebral hypoperfusion has been associated with cognitive decline in aging and
Alzheimer's disease. Moreover, the pattern of cerebral blood flow in mild cognitive …

The prevalence, morphology and pathogenesis of vascular dementia (VaD), recently termed
vascular cognitive impairment, are a matter of discussion, and currently used clinical …

Smith and Markus Cerebral Small Vessel Disease Trials 39 dysmetabolism, and glucose
dysregulation that are the primary targets for current ischemic stroke prevention. As an …

Cerebral small vessel disease (CSVD) refers to a spectrum of clinical and imaging findings
resulting from pathological processes of various etiologies affecting cerebral arterioles …

The accumulation of plaques of β‐amyloid (Aβ) peptides, a hallmark of Alzheimer's disease,
results from the sequential cleavage of amyloid precursor protein (APP) by activation of β …

Abstract Alzheimer's disease (AD), which is characterized by progressive cognitive
impairment, is the most common neurodegenerative disease. Here, we investigated the …

Mitochondria have various roles in cellular metabolism and homeostasis. Because
mitochondrial dysfunction is associated with many acute and chronic degenerative …

BACKGROUND AND PURPOSE Cilostazol may be effective in dementia associated with a
cerebral ischaemia. In this study, we examined whether it exerts beneficial effects on …

5. Dwyer-Lindgren L, Bertozzi-Villa A, Stubbs RW, Morozoff C, Mackenbach JP, van Lenthe
FJ, et al. Inequalities in life expectancy among us counties, 1980 to 2014: temporal trends …

Countless neurodegenerative diseases are associated with perverse multiple targets of
cyclic nucleotide signalling, hastening neuronal death. Cilostazol, a phosphodiesterase-III …